Abstract: Objective To build up a scientific and appropriate followed-up and management model for pregnant women with chronic hepatitis B viral infection to block mother to infant communication. Methods 1103 pregnant women with hepatitis B viral infection and 456 infants were followed-up in our Department of Infectious Diseases,First Affiliated Hospital,Xi'an JiaoTong University between September 2012 and September 2017,and a expert team was responsible for the management of them. We made up two questionnaire on hepatitis B-related knowledge and health demand knowledge and the corresponding intervention measures were taken for them. Results 32.28% of pregnant women accepted breastfeeding,44.33% of them considered natural labor, while most people thought that cesarean delivery might reduce mother to infant transmission of hepatitis B virus infection;41.89% of them accepted antiviral therapy during pregnancy and some worried about the nucleos（t）ide analogues might have a negative impact on the baby growth; out the 1103 pregnant women,the awareness rates of hepatitis B and mother-to-infant transmission knowledge before our intervention were 59.11% and 47.69%,the obedience was 77.61%,while they increased to 83.86%,79.69% and 93.20% （P<0.05） after our education with the satisfactory rate reaching to 89.66%;out of 456 infants who followed the entire the management,2（0.44%） got serum HBsAg positive at age of six months,suggesting the successful blockage of mother to infant transmission in our series was 99.56%（454/456）. Conclusion The establishment of standardized, scientific,reasonable and cultural followed-up and management scheme might increase the successful blockage of mother to child hepatitis B viral transmission, and achieve a “zero” transmission goal.

Key words: Hepatitis B, Pregnancy, Mother to infant transmission, Followed-up management