Abstract: Objective To investigate the impact of laparoscopic cholecystectomy（LC） on blood immunoglobulin levels and on intestinal mucosa in patients with cholelithiasis,Methods 110 patients with cholelithiasis were recruited in our hospital between December 2015 and December 2016,and 55 received open cholecystectomy （OC） and another 55 received LC. Blood cortisol and immunoglobulin were detected,The specimen of intestinal mucosa was obtained under enteroscopy and was examined pathologically by Chiu's criteria. Results At the end of one week after operation,serum C-reactive protein,blood glucose and cortisol levels in LC group were （4.2±0.4） mg/L,（5.5±1.0） mmol/L and（249.4±43.1） ng/ml,much lower than [（5.3±1.0） mg/L,（6.1±1.1） mmol/L and （267.4±46.8） ng/mL in OC group （P<0.05）;serum IgA,IgG and IgM were （1.8±0.3） g/L,（1.0±0.2） g/L and （1.0±0.2） g/L,much higher than （1.4±0.2） g/L,（0.9±0.1） g/L and （0.8±0.1） g/L in the OC group （P<0.05）;at the end of three months after operation, the Chiu's injury of intestinal mucosa was much milder in the LC group than that in the OC group（U value=11.008,P<0.05）;the complication rate in the LC group was 5.4%,much lower than 18.2% in the OC group（P<0.05）. Conclusion s LC might induce little stress and immune reaction,and lead to mild intestinal mucosa injury.

Key words: Cholelithiasis, Laparoscopic cholecystectomy, Stress reaction, Intestinal mucosa