Abstract: 【Abstract】 Objective To investigate the efficacy of ultrasound-guided injection of lauromacrogol in the treatment of patients with simple hepatic cyst. Methods A total of83patients with simple hepatic cyst who were confirmed by B ultrasound, computed tomography （CT） or magnetic resonance imaging （MRI） scan were randomly divided into lauromacrogol-intervened group（n=41）, ethanol-injected group（n=42）, and the patients with hepatic cyst received ultrasound-guided injection of lauromacrogol or ethanol, respectively. The efficacy, blood biochemical index, adverse events were assessed between the two group. Result The clinical data at presentation, such as the age of the patients, gender, diameters of hepatic cyst, the duration of the hepatic cyst history, were not significantly different between the two group（P0.05）. The efficacy at the end of six month follow-up showed that there was no significant differences as respect to the disappearance of the cysts, shrunk cysts between the two groups（P0.05）;there were no significant differences in the blood liver function index before, after the inference between the two groups（P0.05）;the incidence of abdominal distension, abdominal pain （x2=23.11, P0.01） as well as drunkenness（x2=23.11, P0.01） was higher in ethanol-injected group, while the incidence of fever, nausea, vomiting showed no significant differences between the two group（P0.05）. Conclusion The ultrasound-guided intracystic injection of lauromacrogol in the treatment of patients with simple hepatic cyst has the same efficacy as the ultrasound-guided injection of ethanol, with less adverse effects

Key words: Hepatic cyst, Ultrasound-guided injection, Lauromacrogol, Ethanol, Efficacy