Abstract: Objective To evaluate the diagnostic efficacy of ten noninvasive indexes for liver fibrosis in patients with chronic hepatitis B. Methods The data of 1362 patients with chronic hepatitis B between January 2008 and December 2014 were collected and statistically analyzed. Results For significant fibrosis diagnosis,the best AUROCs of S index,GPRI and APRI were 0.745,0.736 and 0.681,respectively;For cirrhosis diagnosis,the best AUROCs were S index（0.716）,FIB-4 （0.708） and GPRI 0.707,respectively;In diagnosing liver cirrhosis,the cut-off value of S index was 0.03,with a sensitivity of 98.8%,a negative predictive value of 97.0% and a negative likelihood ratio of 0.14;and the cut-off value 1.5 showed a specificity of 99.5%,a positive predictive value of 70.0% and a positive likelihood ratio of 10.1;For significant fibrosis diagnosis,the cut-off value of S index was 0.89,with a specificity of 99.5%,a positive predictive value of 98.5% and a positive likelihood ratio of 11.5;the cut-off value 0.02 showed a sensitivity of 97.7%,a negative predictive value of 40.0% and a negative likelihood ratio of 0.26. Conclusions S index has a relatively good accuracy and is superior to other nine noninvasive diagnostic indexes in diagnosing significant liver fibrosis in patients with chronic hepatitis B.

Key words: Hepatitis B, Liver fibrosis, Routine serum biomarker, Noninvasive indexes