Abstract: Objective To analyze the diagnostic value of quantitative analysis of liver fibrosis by real time tissue elastography in patients with hepatitis B. Methods 175 patients with hepatitis B and 100 healthy persons between July 2015 and December 2016 were recruited in our hospital,and liver biopsies were performed in patients with hepatitis B. Real-time tissue elastography （RTE） was conducted in the two groups. The receiver operating characteristic curve （ROC） was used to analyze the efficacy of diagnostic value of each parameter. When the area under curve（AUC） of ROC was greater than 0.5,the diagnosis was set up. Results The average relative value （ARV） in health group was（128.3±8.1）,much higher than （106.3±5.2） in CHB patients （P<0.05）;the area ratio of low-strain region （AREA）,complexity （COMP）,skewness （SKEW）,contrast （CONT） and inverse different moment（IDM） in health group were （3.7±0.5）,（16.6±1.2）,（-0.1±0.0）,（91.8±9.1）,（0.1±0.0）,much lower than [（19.9±2.6）,（29.4±3.1）,（0.3±0.1）,（173.9±17.9）,（0.2±0.1）,all P<0.05） in patients with CHB;the ARV in 67 patients with S0-S1 staging was （118.5±5.6）,much higher than [（101.6±5.3）,P<0.05] in 82 with S2-S3,and also much higher than [（89.7±4.9）,P<0.05] in 26 with S4 staging;the AREA,COMP,SKEW,CONT and IDM in S0-S1 group were（9.4±1.7）,（22.4±2.4）,（0.11±0.0）,（121.0±11.2）,（0.1±0.0）,much lower than[（23.5±2.4）,（31.8±2.7）,（0.32±0.1）,（188.2±15.2）,（0.2±0.1）,all P<0.05） in S2-S3 group,and the AREA,COMP,SKEW,CONT in S2-S3 group were also much lower than[（36.2±2.6）,（40.1±2.9）,（0.46±0.1）,（265.3±16.1）,all P<0.05） in S4 group;ROC curve analysis showed that the ARV,AREA and SKEW had diagnostic value for diagnosis of S0-S1,S2-S3 and S4 as the AUC were greater than 0.5. Conclusion Non invasive diagnosis of quantitative analysis by real time tissue elastography has diagnostic significance for liver fibrosis in patients with hepatitis B,and it might be used as one of the alternative methods for liver fibrosis.

Key words: Hepatitis B, Real time tissue elastography, Liver fibrosis, Non-invasive diagnosis