Abstract: Objective To investigate the changes of serum carbohydrate antigen（CA）125,CA199, alpha-fetoprotein （AFP） and carcinoembryonic antigen （CEA） in patients with live cirrhosis and primary liver cancer（PLC）. Methods Serum levels of CA125,CA199,AFP and CEA in 440 individuals were detected by ELISA,including 223 patients with liver cirrhosis,97 patients with PLC and 120 healthy persons. Results The levels of CA125 in patients with liver cirrhosis and PLC were （261.64±32.47） U/ml and （265.80±30.44 ） U/ml, CA199 were （25.73±3.39） U/ml and （30.54±3.29） U/ml,CEA were （4.03±0.36） ng/ml and （3.87±0.21） ng/ml,much higher than those[（21.25±7.66） U/ml,（18.57±8.11） U/ml and （3.08±1.05） ng/ml,P<0.05] in healthy persons;serum AFP levels in patients with PLC were（20000.00±453.07） ng/ml,much higher than[（7.52±2.01） ng/ml,P<0.05] in patients with liver cirrhosis;The levels of CA125（474.52±59.80） U/ml],CA199 [（27.80±5.94） U/ml] and CEA [（5.80±0.63） ng/ml] in patients with liver cirrhosis of class C were significantly higher than those of class A [（55.65±8.82） U/ml,（18.81±0.46） U/ml and （3.20±0.10） ng/ml,respectively,P<0.05];The levels of CA125[（385.16±36.09） U/ml],CA199[（26.55±2.87） U/ml],AFP[（13.63±1.82） ng/ml] and CEA [（4.85±0.39） ng/ml] in patients with cirrhotic ascites were higher than those without ascites[（62.75±15.45） U/ml,（19.58±0.75） U/ml,（9.39±1.26） ng/ml and （3.54±0.16） ng/ml,P<0.05];The levels of CA125 [（318.48±48.80）U/ml] and CA199 [（26.63±3.22）U/ml] in patients with alcoholic liver cirrhosis were higher than those in patients with viral cirrhosis [（215.77±26.26）U/ml and（19.06±0.64）U/ml,P<0.05] or in patients with primary biliary cirrhosis [（129.73±28.55）U/ml and（18.00±0.00） U/ml,P<0.05];The level of AFP [（56.41±26.75）ng/ml] in patients with viral cirrhosis was higher than[（5.44±0.30） ng/ml or（7.35±1.47） ng/ml,respectively,P<0.05],while the CEA level[（3.53±0.17） ng/ml] was lower than [（5.19±0.35） ng/ml or（5.73±0.98） ng/ml,P<0.05] in patients with alcoholic liver cirrhosis or primary biliary cirrhosis. Conclusion The serum levels of CA125,CA199,AFP and CEA in patients with liver cirrhosis and PLC were different. The serum levels of CA125,CA199,AFP and CEA in patients with liver cirrhosis were associated with Child-Pugh scores,ascites and etiology.

Key words: Primary liver cancer, Liver cirrhosis, Carbohydrate antigen 125, CA199, Alpha-fetoprotein, Carcinoembryonic antigen