Abstract: Liver fibrosis is a wound-healing process in response to chronic liver injury of variety etiologies,which eventually progress to liver cirrhosis during persistent inflammation and fibrogenesis. The hepatic stellate cells（HSC） are the major cell types in the process of liver fibrosis. Excessive production of the extracellular matrix（ECM） is the most special features of fibrosis. A variety of profibrogenic factors such as angiotensin-II（Ang-II）,platelet-derived growth factor（PDGF）,vascular endothelial growth factor（VEGF）,transforming growth factor-β（TGF-β）,leptin and connective tissue factor binding to the corresponding receptors on the HSC surface Results in activation of the corresponding signaling pathways and the activation and proliferation of HSCs,ECM excessive deposition,and hepatic fibrogenesis. Therefore,understanding the relationship of the various profibrogenic factors and liver fibrosis can provide a theoretical basis for scientific research and clinical anti-fibrotic treatment of liver fibrosis.

Key words: Liver fibrosis, Hepatic stellate cells, Profibrogenic factors