Abstract: Objective To explore the effect of polyene phosphatidylcholine combined with vitamin E in treatment of patients with nonalcoholic fatty liver disease and diabetes type 2. Methods Eighty three patients with nonalcoholic fatty liver disease and diabetes type 2 were randomly divided into two groups. Patients in the experimental group were given polyene phosphatidylcholine and vitamin E regularly for eight weeks,and patients in the control group received polyene phosphatidylcholine alone for eitht weeks. Then,the efficacy in the two groups as respect to normalization of blood biochemistry index and serum lipids were compared. ResultsAt the end of treatment,the blood glucose levels in experimental group and in the control group decreased,with a average of 7.6 mmol/L in patients of experimental group and 7.8 mmol/L in patients of the control group;Serum ALT and AST levels in experimental group were （43.8±18.2） IU/L and（42.3±9.6） IU/L,respectively,which were significantly lower than those in the controls[（59.0±10.8） IU/L and （51.5±12.2） IU/L,P<0.05];Blood TG and TC levels in experimental group were（1.50±0.57） mmol/L and （5.09±1.18） mmol/L,respectively,which were significantly lower than those in the controls[（3.00±0.29） mmol/L and（5.78±1.23） mmol/L,P<0.05];The B-mode ultrasound examination index of liver in the experimental group was（1.2±0.3）,significantly lower than that in the controls（1.6±0.3）;The effective rate in the experimental group was 79.5%,significantly higher than that in the controls（54.5%,P<0.05）. Conclusion Polyene phosphatidylcholine combined with vitamin E is more effective in the treatment of patients with nonalcoholic fatty liver disease and diabetes type 2 than polyene phosphatidylcholine alone.

Key words: Nonalcoholic fatty liver disease, Diabetes type 2, Polyene phosphatidylcholine, Vitamin E, Efficacy