Nedd4L与肝纤维化发生关系的研究进展*

doi:10.3969/j.issn.1672-5069.2015.04.030

Abstract

Abstract: Protein encoded by neural precursor cell-expressed developmentally down-regulated gene 4-like（Nedd4L）gene belongs to the ubiquitin ligase E3. Tt is important for ubiquitination and degradation process of intracellular proteins，which involves in the action mode，activation and regulation of Nedd4L. More and more researches points out that cancers，obesity，hypertension and fibrosis are closely related to action of Nedd4L， but the specific mechanisms are far from clear. This review focuses on the fibrogenesis of Nedd4L in liver fibrosis.

Key words: Liver fibrosis, Neural precursor cell-expressed developmentally down-regulated gene 4-like gene, Fibrogenesis

Chen Bangtao，Zhao Zhongfu. Fibrogenesis of neural precursor cell-expressed developmentally down-regulated gene 4-like gene in liver fibrosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(4): 432-436.

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Fibrogenesis of neural precursor cell-expressed developmentally down-regulated gene 4-like gene in liver fibrosis

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