Abstract: Objective To investigate the relationship among serum ALT，AST，GGT，GLO levels and liver tissue injuries in patients with chronic hepatitis B. Methods 486 patients with chronic hepatitis B viral infection were retrospectively analyzed．The histopathologic examinations of liver biopsies were performed in all of them. The liver histological activity index （grading，G） and the fibrotic stage （S） were obtained. And the serum liver function index，the patient's gender，age and other indicators were also recorded. The data was measured by Mann-Whitney U test，or by using t test，and we used Spearman's or Pearson's for correlation analysis. Results Out of 486 patients with chronic hepatitis B，63（12.96%） had liver grading of ≥G2，and 231 （47.5%） had liver fibrosis of ≥S2，and the age was significantly lower in 248 HBeAg-positive group than in 238 HBeAg-negative group[（32.9±10.5）yr vs. （40.6±9.5）yr，P<0.05]，and AKP levels was significantly higher than in HBeAg-negative group（ P＜0.05）；the serum AST，AKP，GGT levels in patients with liver fibrosis of ≥S2 were significantly higher，but serum ALB levels were lower than those in patients with Conclusions Serum AST，GGT，ALB levels are associated with liver fibrosis in patients with seerum ALT less than 2 ULN and liver biopsies are strongly recommended in patients serum ALT less than 2 ULN，no matter serum HBeAg-positive or -negative when antiviral therapy needs to be considered.

Key words: Hepatitis B, Liver histology, Alanine aminotransferase, Globulin