Abstract: Objective To retrospectively analyze the safety and efficacy of transarterial chemoembolization （TACE） by using gelatin sponge microparticles（GSMs） in different diameters in patients with spontaneous rupture of hepatocellular carcinoma（HCC）. Methods From August 2010 to December 2013,11 patients with spontaneous rupture of HCC received GSMs-TACE in Zhongshan Hospital Affiliated to Dalian University. CT scanning and determination of serum AFP levels were performed 1,3 and 6 months after initial GSMs-TACE,and tumor response was evaluated according to mRECIST 1.1 criteria and AFP levels. Results The 11 patients after GSMs-TACE were Followed-up for 1 to 6 months with a mean range of 5 months. 11 patients receiving GSMs-TACE achieved successful rapid hemostasis without technique-related complications;the survival rates at 1,3 and 6 month（s） were 90.9% （10/11）,72.7% （8/11） and 63.6% （7/11）,respectively,and the Objective effective rates were 70.0%,75.0%,71.4%,respectively;the postoperative complications mainly included local pain（100%）,nausea and vomiting （73.0%）,fever（54.5%）;two patient received hepatectomy 10 days and 30 days after GSMs-TACE,respectively. Conclusion TACE using GSMs of different diameters is safe and effective for patients with spontaneous rupture of HCC in the purpose of achieving hemostasis,improving survival rates and even getting the subsequent surgical operation.

Key words: Hepatocellular carcinoma, TACE, Gelatin sponge microparticles, Spontaneous rupture, Hemostasis