Abstract: This review aims to discuss the necessity and feasibility of preventing and controlling hepatitis C virus （HCV） infection in hospitals,and how to take effective strategies of intervention,establish a relatively standard and complete management system,and improve the effectiveness of management continually. The Third Affiliated Hospital of Sun Yat-Sen University enhanced the publicity and training of staffs,introduced the liaison system,and ensured patients’ informed consent. With these efforts,the medical personnel and the patients have increased awareness of HCV infection and paid more attention to it,and the relevant divisions have achieved cross-sectional cooperation and worked well. The percentage of anti-HCV screening to surgical cases and the percentage of HCV RNA screening in cases with anti-HCV positive in 2012 raised by 5.87% and 28.4%,respectively,as compared to in 2011. It is obvious that hospitals are able and necessary to strengthen management of preventing and controlling the HCV infection with effective measures to protect the safety and rights of patients’ and medical personnel’.

Key words: Hepatitis C, Nosocomial infection, Prevention and contro, Management