Abstract: Objective To explore the serum and hepatic level of pancreatic derived factor （PANDER） in patients with non-alcoholic fatty liver diseases （NAFLD）. Methods Forty-one patients with NAFLD confirmed by liver biopsy and 20 healthy persons were included in this study and the patients with NAFLD were further divided into NAFL group （n=10） and NASH group （n=31 cases） according to the NAFLD activity score （NAS）. Serum and hepatic level of PANDER were detected by ELISA method and hepatic level of PANDER mRNA was determined by real-time PCR. Anthropometry data,biochemical and metabolic parameters of all subjects were collected and compared between different groups. Results The serum level and hepatic level of PANDER in patients with NAFLD were（3.38±1.99） ng/ml and（3.27±2.49） ng/ml,respectively,significantly higher than those in healthy controls[（0.94±0.60） ng/ml,（0.98±0.73） ng/ml）,respectively,P<0.05];No significant difference in serum level [（3.42±2.39） ng/ml vs. （3.36±1.91） ng/ml] and hepatic level [（2.33±1.52） ng/ml vs. （3.58±2.68） ng/ml] of PANDER between patients with NAFL and NASH;Serum level of PANDER were positively correlated with hepatic level of PANDER （r=0.425）,BMI（r=0.643）,waist circumference（r=0.637）,hip circumference（r=0.375,triglyceride （r=0.411）,fasting blood glucose（r=0.487）,fasting insulin（r=0.512） and homeostasis model assessment index （HOMA-IR,r=0.547,P<0.05）,and negatively correlated with insulin action index（r=-0.544） and high-density lipoprotein cholesterol（r=-0.396,P<0.05）. Hepatic level of PANDER were positively correlated with serum PANDER level（r=0.425）,body mass index（r=0.379） and waist circumference（r=0.427,P<0.05）. Conclusion PANDER plays an important role in the pathogenesis of NAFLD by affecting body insulin resistance and glucose and lipid metabolisms.

Key words: Nonalcoholic fatty liver diseases, Pancreatic derived factor, Insulin resistance, Lipid, Glucose metabolism