Abstract: Objective To investigate the efficacy of entecavir in the treatment of patients with hepatitis B virus （HBV）-related cirrhosis complicated by hepatogenous diabetes （HD） and its influence on indexes of glucose metabolism. Methods 84 patients with HBV-related cirrhosis complicated by HD were divided into control （n=42） and observation group（n=42） by randomized number table generated by computer. The patients in control group were given antidiabetic,hepatoprotective and other conventional treatment,and at this basis,the patients in observation group were additionally treated with entecavir,and the observation was 48 weeks. After treatment,the virological response rates,serum liver function tests,glucose metabolism indexes and blood liver fibrosis indexes were compared between the two groups. Results The negative conversion rate of serum HBV DNA in the observation group at the end of 48 week treatment was higher than that in the control group （78.6% vs. 16.7%,P<0.05）;at the end 48 weeks,serum total bilirubin （TBIL）,alanine transaminase （ALT） and aspartate transaminase （AST） levels in the observation group were （21.2±4.2） μmol/L,（43.3±12.7） IU/L, （39.4±1.8） g/L, significantly different as compared to those in the control group [（36.1±5.3） μmol/L,（77.1±15.2） IU/L,（33.9±3.4）g/L,respectively,P<0.05];the fasting blood glucose （FBG）,2h postprandial blood glucose （2h PBG）,hemoglobin A1c （HbA1c）,fasting insulin （FINS）,insulin resistance index（HOMA-IR） in the observation group were （5.3±0.7） mmol/L,（7.1±1.5） mmol/L,（6.1±0.6） %,（10.5±2.6） mU/L and（2.1±0.7）,much lower than those in the control group [（6.8±0.8） mmol/L,（10.3±1.6） mmol/L,（7.8±0.7） %,（15.6±4.0） mU/L,（3.1±0.6）,P<0.05];serum laminin （LN）,serum hyaluronic acid （HA）,procollagen III （PC III） and type IV collagen （IV-C） levels in the observation group were （144.3±54.2） μg/L,（81.7±38.7） μg/L,（116.3±31.4） μg/L and（71.2±42.9） μg/L,also much lower than those in the control group [（177.3±63.5） μg/L,（123.1±41.9） μg/L,（165.7±28.6） μg/L and（124.7±39.1） μg/L,P<0.05]. Conclusion Entecavir can inhibit replication of HBV,improve liver function and stabilize HD in patients with HBV-related cirrhosis complicated by HD.

Key words: Cirrhosis, Hepatitis B, Hepatogenous diabetes, Entecavir, Insulin resistance