Abstract: Objective To analyze the clinical features of inpatients with top four kinds of non-infectious liver diseases（NILD） and changing trend of the disease spectrums over the past decade. Methods The clinical data of 12508 of inpatients with NILD in our hospital in the past decade were collected and analyzed with SPSS18.0. The clinical features and changing trend in disease spectrum were explored. Results Patients with alcoholic liver diseases and autoimmune liver diseases accounted for 35.0% and 32.1%,respectively;the ratio of inpatients with alcoholic liver diseases,drug-induced liver injury and autoimmune liver diseases to total inpatients with liver diseases increased 2.4,2.3 and 2.1-fold,respectively over the past decade;the percentage of male patients with alcoholic liver diseases and non-alcoholic fatty liver diseases accounted for 97.7% and 77.7%, respectively,while the percentage of female patients accounted for 84.3% and 57.9%,respectively（P<0.01）in patients with autoimmune liver diseases and drug-induced liver injury;the average age of patients with autoimmune liver diseases was（47.6±10.6） years, while it was [（35.9±14.1） years,P<0.01） in patients with non-alcoholic fatty liver diseases;the patients in the age range of 40 to 49 years accounted for 37.1% and 25.0%,respectively,in patients with alcoholic liver diseases and drug-induced liver disease,while the patients in the age range of 50 to 59 years and 30 to 39 years accounted for 33.7% and 25.3%,respectively（P<0.01）in patients with autoimmune liver diseases and non-alcoholic fatty liver diseases. Conclusions The ratio of patients with NILD to total patients with liver diseases is increasing gradually over the past decade and more attention should be paid for the management of those patients.

Key words: Non-infectious liver disease, Clinical features, Changing trend, Comparative analysis