慢性丙型肝炎患者HCV基因型分析

doi:10.3969/j.issn.1672-5069.2012.05.006

Abstract

Abstract: Objectives To investigate the genotypes of hepatitis C virus in patients with chronic hepatitis C. Method The genotypes of hepatitis C virus was detected by gene chips and serum hepatitis C viral RNA was assayed by RT-PCR. Results Out of 570 sera,552（95%） were positive for HCV RNA,and 1b were positive in 400 （72.4%）,2a in 63（11.4%）,3a in 20（3.6%）,3b in 20 （3.6%）,1b+2a in 12 （2.1%）,1a in 2 （0.4%）,6 in 7（1.26%）,1b+3a in one（0.18%）,2a+1b in 3（0.5%）,and unknown in 24（4.3%）;Serum HCV RNA levels in patients with different hepatitis C viral genotype infection were not significantly different（P>0.05）. Conclusion The hepatitis C virus of genotype 1b dominated,and 2a in the second place in our series; Some mix infection with multiple genotypes needs further investigation.

Key words: Hepatitis C, Genotypes of hepatitis C virus, HCV RNA

Pan Jian, Yu Haiying, Ding Qiaoyun, et al.. Genotypes of hepatitis C virus in patients with chronic hepatitis C[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2012, 15(5): 390-391.

References

[1] 中华医学会. 丙型肝炎防治指南.中华肝脏病杂志,2004,12（4）:194-198.
[2] 张英,朱建英,曾丽娇,等. 聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎. 热带医学杂志,2008,8（8）：810-812.
[3] Yamada G,Takatani M,Kishi F,et al. Efficacy of interferon alfatherapy in chronic hepatitis C virus RNA level. Hepatology,1995,22：1351.
[4] Hayes CN,Kobayashi M,Akuta N. HCV substitutions and IL28B polymorphisms on outcome of peg -interferon plus ribavirin combination therapy. Gut,2011,60（2）：261-267.
[5] 廖祥伟,凌云,李新华,等. 宿主IL28B 基因型联合病毒基因型对慢性丙型肝炎抗病毒疗效的预测. 中国病毒病杂志,2011,1：35-40.
[6] Simmonds P,Holmes EC,Cha TA,et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol,1993,74（11）:2391-2399.
[7] Moreno C,Deltenre P,Pawlotsky JM,et al. Shortened treatment duration in treatment-naive genotype 1 HCV patients with rapid virological response: a meta analysis. J Hepatol,2010,52（1）:25-31.
[8] Mangia A,Santoro R,Andriulli A,et al. Peginterferon alfa-2b and ribavirin for 12 vs. 24 weeks in HCV genotype 2 or 3. N Engl J Med,2005,352（25）:2609-2617.
[9] Davis GL,Wong JB,McHutchison JG,et al. Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C. Hepatology,2003,38（3）: 645-652.
[10] Wong JB,Davis GL,McHutchinson JG,et al. Clinical implications of testing viral response during ribavirin and peginterferon alfa-2b treatment for chronic hepatitis C. Hepatology,2002,36:281A.
[11] Yuen MF,Lai CL. Response to combined interferon and ribavirin is better in patients infected with hepatits C virus genotype 6 than genotype 1 in HongKong.Intervirology,2006,49（1-2）：96-98.
[12] 张永祥,孙南雄,黄祖瑚,等. 江苏地区丙型肝炎病毒基因分型研究. 江苏医药,2004,30（6）：463-464.
[13] 张大军. 60例丙型肝炎患者血清丙型肝炎病毒RNA的基因分析. 中华流行病学杂志,2002,23（6）:469.

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Genotypes of hepatitis C virus in patients with chronic hepatitis C

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