Abstract: Objective To investigate the efficacies of interferon alfa-1b and ribavirin in treatment of patients with chronic hepatitis C of different genotypes. Methods The genotypes of hepatitis C virus in 106 patients with hepatitis C were detected by genotype-specific probes. The patients with hepatitis C were treated with interferon alfa-1b and ribavirin for 48 weeks. Results Out of 106 patients with hepatitis C,the HCV genotype 3b accounted for 45.3%,1b for 20.8%,and 3a for 18.9%,while we still detected some 6a（9.4%）and 2a（5.7%） positive;Nine out of 22 patients with hepatitis C of 1b and other 82 with non-1b finished the regimen;the rapid virological response and early virological response in patient with non-1b were 50% and 86.6%,respectively;22.2%（2/9）of 1b infected patients got sustained virological response,while 76.8%（63/82）of non-1b got SVR。Conclusion Interferon alfa-1b and ribavirin regimen can be selected for hepatitis C patients with non-1b infection.

Key words: Hepatitis C, HCV genotypes, Interferon alfa, Ribavirin, Efficacy