声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究

doi:10.3969/j.issn.1672-5069.2012.02.011

Abstract

Abstract: Objective The virtual touch tissue quantification（VTQ） technique was used to measure spleen shear wave velocity（SWV） for the evaluation of liver fibrosis in patients with chronic hepatitis B. Method 51 patients with chronic hepatitis B,39 with liver cirrhosis and 32 healthy persons were included and their values of SWV in regions of interest of spleen were performed by VTQ technique. Result The values of SWV were 2.0±0.2,2.3±0.4 and 3.1±0.5,respectively in healthy persons,patients with hepatitis B and liver cirrhosis,and they were significantly different among the three groups（P=0.000）;The SWV values increased as the severity of liver fibrosis progressed. Conclusion The VTQ technique could quantitatively reflect the SWV values and noninvasively evaluate the spleen stiffness,which might be an alternative assessment of liver fibrosis in patients with hepatitis B.

Key words: Hepatitis B, Liver fibrosis, Virtual touch tissue quantification technique, Shear wave velocity

Zhang Chunlin, Tong Qingping, Luo Fucheng, et al.. The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2012, 15(2): 114-116.

References

[1] 中华医学会传染病与寄生虫病学分会和肝病学分会.病毒性肝炎防治方案. 肝脏,2000,5（4）：257-262.
[2] Kanamoto M,Shimada M,Ikegami T,et al. Real time elastography for noninvasive diagnosis of liver fibrosis. J Hepatobiliary Pancreat Surg,2009,16（4）:463-467.
[3] De Lédinghen V,Vergniol J. Transient elastography for the diagnosis of liver fibrosis. Expert Rev Med Devices,2010,7（6）:811-823.
[4] Karlas T,Pfrepper C,Wiegand J,et al. Acoustic radiation force impulse imaging （ARFI） for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease. Scand J Gastroenterol,2011,46（12）:1458-1467.
[5] 刘龙,杜联芳. 声脉冲辐射力成像技术的临床研究进展. 中国医学影像技术,2011,27（6）：1287-1290.
[6] Sporea I,Vlad M,Bota S,et al. Thyroid stiffness assessment by acoustic radiation force impulse elastography（ARFI）. Ultraschall Med,2011,32（3）:281-285.
[7] Tozaki M,Saito M,Joo C,et al. Ultrasonographic tissue quantification of the breast using acoustic radiation force impulse technology:phantom study and clinical application. Jpn J Radiol,2011,29（8）:598-603.
[8] Gallotti A,Donofrio M,Pozzimucelli R. Acoustic radiation force impulse（ARFI）technique in ultrasound with virtual touch tissue quantification of the upper abdomen. Radiol Med,2010,115（6）:889-897.
[9] Popescu A,Sporeal I,Sirli R,et al. The mean values of liver stiffness assessed by acoustic radiation force impulse elastography in normal subjects. Med Ultrasonogr,2011,13（1）:33-37.
[10] D’Onofrio M,Gallotti A,Pozzi MR. Tissue quantification with acoustic radiation force impulse imaging: Measurement repeatability and normal values in the healthy liver. Am J Roentgenol,2010,195（1）:132-136.
[11] Kinan R,Janet C,Ingmar M,et al. Clinical feasibility of liver elastography by acoustic radiation force impulse imaging （ARFI）. Dig Liver Dis,2011,43（6）:491-497.
[12] Sporea I,Sirli R,Popescu A,et al. Acoustic radiation force impulse（ARFI）-a new modality for the evaluation of liver fbrosis. Med Ultrasonogr,2010,12（1）:26-31.
[13] Takahashi H,Ono N,Eguchi Y,et al. Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease:a pilot study. Liver Int,2010,30（4）:538-545.
[14] Sporea I,sirli R,Popescu A,et al. Is it better to use two elastographic methods for liver fibrosis assessment. World J Gastroenterol,2011,17（33）:3824-3829.
[15] Sporea I,Sirli R,Bota S,et al. Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis. World J Radiol,2011,3（7）:188-193.

The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis

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