Abstract: Objective To analyze the clinical features of hepatogenous diabetes（HD）in patients with liver cirrhosis. Methods Clinical data of 45 patients with HD arising from liver cirrhosis were analyzed retrospectively. Results Of the 45 cases，there were 31 patients（68.9%）with hepatitis B virus（HBV）-related liver cirrhosis.The fasting plasma glucose（FPG）level was 7.3±2.9mmol/L and the 2-hour postprandial plasma glucose（PPG） level was 16.2±4.7mmol/L. FPG level was positively correlated with Child-Pugh score（rs=0.48，P＜0.01）. Most patients showed normal or nearly normal plasma glucose levels after they received the treatment with diet controls combined with alpha-glucosidase inhibitors or insulin. 7 patients died of the complications of liver cirrhosis. Conclusion The symptoms of diabetes mellitus in patients with HD are atypical. HD is characterized by high PPG level. Plasma glucose level correlates strongly with liver dysfunction. Insulin treatment is effective for most patients with HD. Poor prognosis is closely related to liver cirrhosis.

Key words: Liver cirrhosis, Hepatogenous diabetes, Insulin resistance