Abstract: Objective To evaluate the efficacy of adefovir dipivoxil treatment on patients with chronic hepatitis B. Methods Adefovir dipivoxil and lamivudine were given to 39 patients with HBeAg-positive，and adefovir dipivoxil was given to 12 with HBeAg-positive and to 14 with HBeAg-negative hepatitis B，respectively for 24 weeks. Results Serum HBV DNA undetectable rates at 3 mon，6 mon，12 mon and 24 mon both in HBeAg-positive patients with adefovir dipivoxil and lamivudine or in HBeAg-negative patients with adefovir dipivoxil alone were higher than in HBeAg-positive patients with adefovir dipivoxil alone；the normalization of ALT in the three groups were not significantly different. Conclusion We recommend combination of adefovir dipivoxil and lamivudine therapy for patients HBeAg-positive hepatitis B.

Key words: Hepatitis B, Adefovir dipivoxil, Lamivudine, Efficacy