肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义*

doi:10.3969/j.issn.1672-5069.2010.06.009

Abstract

Abstract: Objective To investigate the serum levels of extracellular matrix protein 1（ECM1），matrix metalloproteinase-9（MMP-9）and vascular endothelial growth factor（VEGF）in patients with HCC. Methods Serum levels of ECM1，MMP-9 and VEGF were detected by enzyme-linked immunosorbent assay in 40 patients with HCC. Results The serum ECM1，MMP-9 and VEGF levels were 150.01±5.85pg/ml，467±30.81μg/l and 751.29±51.08pg/ml；The serum levels of them were significantly associated with tumor capsula，TNM stage，lymph metastasis and Edmondson grade；ECM1 levels was positively correlated with MMP-9 and VEGF levels（r=0.438，P=0.005；r=0.427，P=0.006）.Conclusion ECM1 may stimulate angiogenesis，metastasis and invasion of HCC via interaction with MMP-9 and VEGF.

Key words: Hepatoma, Extracellular matrix protein 1, Vascular endothelial growth factor, Matrix metalloproteinase-9

CHEN Hao，LI Jiansheng，JIA Weidong，et al.. Serum levels of extracellular matrix protein 1，MMP-9 and VEGF in patients with hepatocellular carcinoma[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2010, 13(6): 424-427.

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Serum levels of extracellular matrix protein 1，MMP-9 and VEGF in patients with hepatocellular carcinoma

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