Abstract: Objectives To explore the influence of HBV DNA on prognosis in early,middle and advanced stages of chronic severe hepatitis B patients. Methods To add up the information of HBV DNA in 197 patients in different stages of chronic severe hepatitis B from 2004 to 2008 in our hospital. To measure the three-month mortality of HBV DNA positive group and HBV DNA negative group in early stage,middle stage and advanced stage. To count the changes of model for end-stage liver（MELD） values on two weeks after admission. Results In early stage the three-month mortality of HBV DNA positive group and HBV DNA negative group were 34% and 7.4% respectively（P<0.01）. In middle stage and advanced stage the rates of two groups were 48.8% and 44.4%（P>0.05）,80% and 76.9%（P>0.05）. In early stage △MELD values on two weeks after admission of HBV DNA positive group and HBV DNA negative group were 3.6±4.8 and 0.8±4.1 respectively（P=0.01）. In middle stage and late stage the values of two groups were 1.5±4.2 and 1.1±6.5（P>0.05）,-1.6±7.3 and-1.1±5.8（P>0.05）. Conclusions HBV DNA positive influenced the prognosis of chronic severe hepatitis B in early stage,but not in middle stage and advanced stage.

Key words: Chronic severe hepatitis B, HBV DNA, Prognosis