关键词: 失代偿期肝硬化, 自体骨髓干细胞, 细胞治疗

Abstract: Objective This study aims to observe the curative effect and safety of auto-marrow stem cells in treatment of patients with decompensated liver cirrhosis. Methods 97 cases with decompensated liver cirrhosis were randomly divided into control group（with conventional therapy）and therapy group（with treatment of auto-marrow stem cells on the base of conventional therapy）. The clinical effectiveness，blood biochemical index and adverse events after 1，2，3，4，8 weeks were observed. Results All patients in therapy group had obviously their improvement in clinical symptoms after treatment，while only 4.2% patients improved in control group；The level of albumin after 8 weeks was 33.1±8.3g/L in study group，much higher than 25.6±7.6g/L in control group（P<0.05）；The prothrombin time activity were 43.0±11.4% and 38.2±12.5% in the two groups，respectively（P<0.05）；The TBIL were 38.3±12.2 μmol/L and 40.6±13.3 μmol/L，respectively（P>0.05）；The level of AFP， leukocyte and platelet counts had no difference between the two groups. Conclusion The curative effect of auto-marrow stem cells in treatment of patients with decompensated liver cirrhosis is safe and effective.

Key words: Decompensated liver cirrhosis, Auto-marrow stem cells, Cell treatment