[1] Hui RWH, Seto WK, Cheung KS, et al. Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study. J Viral Hepat, 2018, 25(1): 97-104. [2] Yang J, Chen X, Zhang H, et al. HBV genotype C strains with spontaneous YMDD mutations may be a risk factor for hepatocellular carcinoma. J Med Virol, 2014, 86(6): 913-917. [3] Kao JH, Chen PJ, Lai MY, et al. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology, 2003, 124(2): 327-334. [4] Park YM, Jang JW, Yoo SH, et al. Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma. J Viral Hepat, 2014, 21(3): 171-177. [5] Zhang Y, Yan Q, Gong L, et al. C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism. Oncogene, 2021, 40(6): 1147-1161. [6] Mao X, Tey SK, Ko FCF, et al. C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis. Cancer Lett, 2019, 444: 60-69. [7] Toh ST, Jin Y, Liu L, et al. Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations. Carcinogenesis, 2013, 34(4): 787-798. [8] Jiang Y, Han Q, Zhao H, et al. The mechanisms of HBV-induced hepatocellular carcinoma. J Hepatocell Carcinoma, 2021, 8: 435-450. [9] Cougot D, Wu Y, Cairo S, et al. Correction: The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. J Biol Chem, 2020, 295(9): 2888. [10] Martin-Lluesma S, Schaeffer C, Robert EI, et al. Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1. Hepatology, 2008, 48(5): 1467-1476. [11] Liu H, Shi W, Luan F, et al. Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. Virus genes, 2010, 40(2): 174-182. [12] Mohammadizad H, Shahbazi M, Hasanjani Roushan MR, et al. TIM-3 as a marker of exhaustion in CD8(+) T cells of active chronic hepatitis B patients. Microb Pathog, 2019, 128: 323-328. [13] Lim CJ, Lee YH, Pan L, et al. Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma. Gut, 2019, 68(5): 916-927. [14] Fu J, Xu D, Liu Z, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology, 2007, 132(7): 2328-2339. [15] Peppa D, Micco L, Javaid A, et al. Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS Pathog, 2010, 6(12): e1001227. [16] De Minicis S, Agostinelli L, Rychlicki C, et al. HCC development is associated to peripheral insulin resistance in a mouse model of NASH. PloS One, 2014, 9(5): e97136. [17] Kudo Y, Tanaka Y, Tateishi K, et al. Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. J Hepatol, 2011, 55(6): 1400-1408. [18] Chettouh H, Lequoy M, Fartoux L, et al. Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma. Liver Int, 2015, 35(10): 2203-2217. [19] Sorrentino P, D'angelo S, Ferbo U, et al. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol, 2009, 50(2): 351-357. [20] He G, Karin M. NF-κB and STAT3-key players in liver inflammation and cancer. Cell Res, 2011, 21(1): 159-168. [21] Ding J, Zhao J, Huan L, et al. Inflammation-induced long intergenic noncoding RNA (LINC00665) increases malignancy through activating the double-stranded RNA-activated protein kinase/nuclear factor Kappa B pathway in hepatocellular carcinoma. Hepatology, 2020, 72(5): 1666-1681. [22] Huang H, Zhang J, Ling F, et al. Leptin receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7. Cancer Cell Int, 2021, 21(1): 4. [23] Stefanou N, Papanikolaou V, Furukawa Y, et al. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. BMC cancer, 2010, 10: 442. [24] Sharma D, Wang J, Fu PP, et al. Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. Hepatology, 2010, 52(5): 1713-1722. [25] Xing SQ, Zhang CG, Yuan JF, et al. Adiponectin induces apoptosis in hepatocellular carcinoma through differential modulation of thioredoxin proteins. Biochem Pharmacol, 2015, 93(2): 221-231. [26] Ma C, Kesarwala AH, Eggert T, et al. NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature, 2016, 531(7593): 253-257. [27] Wolf MJ, Adili A, Piotrowitz K, et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer cell, 2014, 26(4): 549-564. [28] Chan AW, Wong GL, Chan HY, et al. Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B. J Gastroenterol Hepatol, 2017, 32(3): 667-676. [29] Choi HSJ, Brouwer WP, Zanjir WMR, et al. Nonalcoholic steatohepatitis is associated with liver-related outcomes and all-cause mortality in chronic hepatitis B. Hepatology, 2020, 71(2): 539-548. [30] Pereira Tde A, Witek RP, Syn WK, et al. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest, 2010, 90(12): 1690-1703. [31] Rangwala F, Guy CD, Lu J, et al. Increased production of sonic Hedgehog by ballooned hepatocytes. J Pathol, 2011, 224(3): 401-410. [32] Liang H, Liu Y, Jiang X, et al. Impact of hepatic steatosis on the antiviral effects of PEG-IFNα-2a in patients with chronic hepatitis B and the associated mechanism. Gastroenterol Res Pract, 2020, 2020: 1794769. [33] Jin X, Chen YP, Yang YD, et al. Association between hepatic steatosis and entecavir treatment failure in Chinese patients with chronic hepatitis B. PloS One, 2012, 7(3): e34198. |