维生素D及其受体抗肝癌作用研究进展

doi:10.3969/j.issn.1672-5069.2015.05.034

摘要/Abstract

摘要： 肝癌具有生存期短、病死率高及发病隐匿等特点，目前仍是慢性病毒性肝炎和肝硬化患者的主要死亡原因。近年研究发现，维生素D可通过与其受体结合而抑制细胞增殖、诱导细胞凋亡和分化，从而发挥抗肿瘤作用。本文简要综述了近年有关维生素D及其受体结合抑制肝癌发生发展的作用机制及维生素D受体基因多态性、维生素D类似物与肝癌发生发展的关系研究进展，以期为肝癌的治疗提供临床依据。

关键词: 肝细胞癌, 维生素D, 维生素D受体

Abstract: Hepatocellular carcinoma（HCC） is the main cause of death in patients with chronic viral hepatitis and cirrhosis，which is characterized by hidden onset，short lifetime and high mortality. It was recently identified that vitamin D，binding with its receptor，may play an important role in anti-tumor effects by inhibiting cell proliferation and inducing cell apoptosis and differentiation. This paper mainly reviewed the recent studies on mechanism of vitamin D and its receptor in inhibiting carcinogenesis，as well as the relationship between vitamin D receptor gene polymorphism and vitamin D analogue in patients with HCC，in order to provide clinical application in the treatment of HCC.

Key words: Hepatocellular carcinoma, Vitamin D, Vitamin D receptor

李玉苓，张颖，赵彩彦. 维生素D及其受体抗肝癌作用研究进展[J]. 实用肝脏病杂志, 2015, 18(5): 567-570.

Li Yuling，Zhang Yin，Zhao Caiyan. Cross-talk between vitamin D and its receptors in hepatocellular carcinogenesis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(5): 567-570.

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