关键词: 药物性肝损伤, 预后, 肝功能指标

Abstract: Objective To investigate the prognostic factors of drug-induced liver injury（DILI）. Methods Sixty-nine patients with DILI were included in this study from July 2008 to July 2014. The factors were assessed by Logistic regression analysis. Results The ages of patients with DILI were mainly among 50 to 59 year old. The number of female patients was more than male ones. The most common clinical manifestation in this series was hepatocyte type（78.3%）,the second was cholestasis type and the third was mixed type. The patients at different ages had no significant difference in clinical types（P>0.05）. The recovered patients accounted for 76.1%,and the unrecovered one was 23.9%. TCM-induced DILI accounted for 43.5% of patients and their prognosis was relatively poor.The prognosis of DILI was not associated with age,gender,and underlying chronic diseases（P>0.05）,but significantly associated with the clinical type,history of allergies and immune characteristic clinical manifestation（P<0.05）. The total bilirubin,total bile acid and alkaline phosphatase were the independent predictors for prognosis of DILI patients（P<0.05）. Conclusion The prognosis of patients with DILI mainly depends on the drug category and the individual physical features.

Key words: Drug-induced liver injury, Prognosis, Hepatic function index