转化生长因子-β1在乙型肝炎病毒感染相关肝病发病中的作用研究进展

doi:10.3969/j.issn.1672-5069.2014.02.027

摘要/Abstract

摘要： 转化生长因子-β1（TGF-β1）是一种具有广泛生物学功能的细胞因子。TGF-β1可能参与了介导免疫细胞数量和功能的异常而诱导免疫耐受，使乙型肝炎病毒（HBV）感染慢性化，但同时可能通过多种途径参与抑制HBV复制；TGF-β1促进肝纤维化发生，对肝癌发生起双向调节作用，同时参与肝衰竭的发生。

关键词: 乙型肝炎, 转化生长因子-β1, 肝纤维化, 肝细胞癌, 肝衰竭

Abstract: Transforming growth factor-β1 （TGF-β1） is a kind of cytokine with broad biological functions. It induces abnormality in cell number and function of immune cells and results in chronic infection of hepatitis B virus （HBV）；At the same time，TGF-β1 inhibits HBV replication through different ways；TGF-β1 also promotes liver fibrosis，affects hepatocellular carcinoma in a dual manner，and plays a significant role in the development of liver failure.

Key words: Hepatitis B, Transforming growth factor-β1, Liver fibrosis, Hepatocellular carcinoma, Liver failure

徐超综述，马勇审校. 转化生长因子-β1在乙型肝炎病毒感染相关肝病发病中的作用研究进展[J]. 实用肝脏病杂志, 2014, 17(2): 206-209.

Xu Chao， Ma Yong.. Pathogenesis effects of transforming growth factor-β1 in hepatitis B virus infection-related liver diseases[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(2): 206-209.

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