乙型肝炎病毒基因突变与临床疾病进展的关系

doi:10.3969/j.issn.1672-5069.2014.02.028

摘要/Abstract

摘要： 乙型肝炎病毒感染人体可以引起急性和慢性乙型肝炎病毒感染。慢性乙型肝炎病毒感染后疾病的转归包括慢性肝炎、肝硬化、肝细胞癌以及肝衰竭。宿主、病毒因素及它们相互作用影响着疾病的进程。HBV基因突变导致病毒生物学特性改变是影响乙型肝炎病毒感染转归的重要因素之一。

关键词: 乙型肝炎病毒, 基因突变, 预后

Abstract: Hepatitis B virus infection may result in acute or chronic hepatitis B. The outcomes of chronic hepatitis B virus infection include chronic hepatitis，cirrhosis，hepatocellular carcinoma and liver failure. Host，virus factors and their interactions affect disease progression. The change in biological characteristics caused by HBV gene mutations is one of the pivotal factors determining the outcomes of HBV infection.

Key words: Hepatitis B, Gene mutation, Disease prognosis

李梵综述，陈国凤，徐东平审校. 乙型肝炎病毒基因突变与临床疾病进展的关系[J]. 实用肝脏病杂志, 2014, 17(2): 210-213.

Li Fan, Chen Guofeng，Xu Dongping.. Hepatitis B viral gene mutation and disease progression in patients with hepatitis B virus infection[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(2): 210-213.

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