关键词: 非酒精性脂肪性肝病, 冠状动脉粥样硬化性心脏病, 冠状动脉CT血管成像, ¹⁸F-FDG摄取量, 诊断

Abstract: Objective The aim of this study was to investigate the diagnosis of coronary atherosclerotic heart disease (CHD) in patients with nonalcoholic fatty liver disease (NAFLD) by coronary artery CT angiography (CCTA) and ¹⁸F-FDG positron emission computed tomography (PET/CT). Methods 120 patients with NAFLD were recruited in our hospital between January 2020 and December 2021, and all underwent CCTA and PET/CT scan. The myocardial and liver standard uptake values (SUV) were obtained and recorded as SUVmyo, SUVliv and SUVmyo/SUVliv ratio(SUVratio). Results Out of the 120 patients with NAFLD, the CCTA found CHD in 28 cases (23.3%); the body mass index, fasting blood glucose, total cholesterol and triglyceride levels in patients with NAFLD and CHD were(28.6±2.2)kg/m²,(6.9±2.1)mmol/L, (6.3±0.9)mmol/L and (3.7±0.4)mmol/L, all significantly higher than[(25.1±2.3)kg/m², (5.2±1.5)mmol/L, (4.4±0.5)mmol/L and (1.6±0.2)mmol/L, P<0.05], and the concomitant proportions of metabolic syndrome, hypertension and diabetes were 28.6%, 32.1% and 28.6%, all much higher than 2.1%, 10.8% and 4.3%(P<0.05) in patients with NAFLD; the CCTA scan showed the non-calcified plaque and non-calcified plaque stenosis in coronary arteries in patients with CHD were 28.6% and 25.0%, both much higher than 4.3% and 2.2%(P<0.05) in patients with NAFLD; the ¹⁸F-FDG PET/CT scan demonstrated that the SUVmyo and the SUVratio in patients with CHD were (3.8±1.1) and (1.6±0.3), both significantly lower than[(6.8±1.6) and (3.1±0.9), respectively, P<0.05] in patients with NAFLD alone. Conclusion The screening of CHD in patients with NAFLD by CCTA and PET/CT scan is convenient and safe, which might be verified by coronary angiography.

Key words: Non-alcoholic fatty liver diseases, Coronary atherosclerotic heart disease, ¹⁸F-FDG intake, Coronary artery CT angiography, Diagnosis