关键词: 原发性胆汁性胆管炎, 肝硬化, 熊去氧胆酸, 甲状腺激素, 治疗

Abstract: Objective To investigate serum thyroid hormone level changes in patients with primary biliary cholangitis （PBC） receiving ursodeoxycholic acid therapy. Methods 70 patients with primary biliary cholangitis,95 with primary liver cirrhosis,and 20 healthy persons were recruited in our hospital between January 2016 and June 2017,and all patients were treated with ursodeoxycholic acid（UDCA） for three months. Serum biochemical tests and thyroid hormone levels were detected before and after 3 month treatment. Results At the end of 3 month treatment,the liver function tests in patients with cholangitis and liver cirrhosis were improved;at presentation,serum TT3,FT3,TT4 and FT4 levels in patients with liver cirrhosis were 1.6±0.2 nmol/L,3.2±0.4 pmol/L,95.6±28.7 nmol/L and 10.3±3.6 pmol/L,and in patients with cholangitis were 1.1±0.2 nmol/L,3.0±0.3 pmol/L,88.2±26.7 nmol/L and 9.7±2.5 pmol/L,all significantly lower than 2.5±0.5 nmol/L,4.7±0.8 pmol/L,115.7±31.6 nmol/L and 13.8±4.1 pmol/L in healthy persons（P<0.05）,while serum TSH levels in the three groups were not significantly different （2.9±0.5 mIU/L and 2.9±0.7 mIU/L vs. 3.3±0.6 mIU/L,respectively,P>0.05）;at the end of 3 month treatment,serum TT3,FT3,TT4 and FT4 levels in patients with cholangitis were 2.4±0.6 nmol/L,4.5±0.8 pmol/L,108.2±36.2 nmol/L and 12.9±3.5 pmol/L,not significantly different as compared to those in healthy persons,while they were 1.2±0.3 nmol/L,3.4±0.4 pmol/L,93.7±29.8 nmol/L and 9.9±3.1 pmol/L in patients with liver cirrhosis,still significantly lower than those in healthy persons（P<0.05）. Conclusion The thyroid hormone levels decrease and might be improved after the treatment of ursodeoxycholic acid in patients with primary biliary cholangitis,which should start as early as possible.

Key words: Primary biliary cholangitis, Liver cirrhosis, Ursodeoxycholic acid, Thyroid hormones, Therapy