关键词: 肝硬化, 病因, 低钠血症, Child-Pugh分级

Abstract: Objective To analyze the etiology and complications of patients with liver cirrhosis. Methods Retrospective analysis of etiology and complications of patients with liver cirrhosis was performed with data collected from 2007 to 2016 in the Department of Gastroenterology,Department of Infectious Disease,and Department of Hepatobiliary Surgery in our hospital. Results In total,the data of 2890 patients with liver cirrhosis were collected and analyzed. Among them,cirrhosis caused by chronic hepatitis B was found in 1632 cases （56.5%）,alcoholic liver disease in 216 cases （7.5%）,chronic hepatitis B and alcoholic liver disease in 475 cases （16.4%）,nonalcoholic fatty liver disease in 37 cases （1.3%）,autoimmune liver disease in 218 cases （7.5%）;Comparing to the data before 2011,the proportion of chronic hepatitis B reduced from 60.22 to 56.5%,alcoholic liver disease increased from 5.3% to 9.0%,and hepatitis C increased from 1.5% to 2.8%;The most common complications of liver cirrhosis in our series were liver cancer in 628 cases（21.7%）,spontaneous peritonitis in 596 cases （20.6%）,hyponatremia in 539 cases（18.7%）,and upper gastrointestinal bleeding in 512 cases （17.7%）;Serum levels of sodium in cirrhosis was found to be negatively correlated with Child-Pugh class,and also negatively with the occurrence of mortality,and the morbidity of hepatic encephalopathy,spontaneous bacterial peritonitis and hepatorenal syndrome. Conclusion Although the constituent ratio of HBV is decreasing during the past decade,it is still the leading etiology of liver cirrhosis. Conversely,alcoholic liver disease and hepatitis C virus infection increase. As one of the common complications of liver cirrhosis,hyponatremia is closely associated with the severity of liver disease,and has a poor prognosis. Clinicians should prevent the occurrence of hyponatremia,especially severe hyponatremia according to its causes.

Key words: Liver cirrhosis, Etiology, Hyponatremia, Child-Pugh class