枯否氏细胞在肝损伤中的作用研究进展

doi:10.3969/j.issn.1672-5069.2016.05.034

摘要/Abstract

摘要： 枯否氏细胞在肝脏组织中起重要的保护屏障作用。在内毒素血症相关肝损伤中,枯否氏细胞与模式相关分子受体如Toll样受体结合,主要产生促炎细胞因子及其它化学分子,进而加速肝损伤的进程,而在药物性（如对乙酰氨基酚）肝损伤中,枯否氏细胞能分泌抗炎因子,促进肝脏血管生成,从而起保护作用。本文就近年来内毒素血症相关肝损伤和药物性肝损伤研究进展,对枯否氏细胞在肝脏损伤中的重要作用加以介绍。

关键词: 肝损伤, 枯否氏细胞, 内毒素血症, 对乙酰氨基酚

Abstract: Kupffer cells serve as a protective barrier in the liver tissues. In endotoxinemia-induced liver injury,Kupffer cells produce pro-inflammatory cytokines and other chemical factors as they coupled with pattern recognition receptors such as Toll-like receptor,which can accelerate the processing of liver injury. Conversely,in drug-induced liver injury,such as acetaminophen-induced liver injury,Kupffer cells play several protective roles via secreting anti-inflammatory cytokines and promoting the formation of blood vessels in liver tissues. In this paper,we reviewed the vital role of Kupffer cells in the two types of liver injuries.

Key words: Liver injuries, Kupffer cells, Endotoxinemia, Acetaminophen

尤娜综述, 朱进, 汪茂荣审校. 枯否氏细胞在肝损伤中的作用研究进展[J]. 实用肝脏病杂志, 2016, 19(5): 633-636.

You Na, Zhu Jin, Wang Maorong.. Roles of Kupffer cells in liver injuries[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(5): 633-636.

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