实用肝脏病杂志 ›› 2010, Vol. 13 ›› Issue (5): 352-356.doi: 10.3969/j.issn.1672-5069.2010.05.012

• 论著 • 上一篇    下一篇

血浆置换联合血液透析滤过治疗重型肝炎的临床观察

郁国强,曾军红,禤江华,李红军   

  1. 545007 广西壮族自治区柳州市 柳铁中心医院感染病科(郁国强,曾军红,禤江华,李红军)
    南方医科大学附属柳州医院感染病科(郁国强)
  • 收稿日期:2010-04-13 出版日期:2010-10-10 发布日期:2016-04-18
  • 作者简介:郁国强 男,45岁,硕士研究生,副主任医师,科主任。从事感染性疾病的临床工作。E-mail: yu.guoqiang0307@163.com

Plasma exchange and hemodialysis filtration in treatment of patients with fulminant hepatitis

YU Guoqiang,ZENG Junhong,XUAN Jianghua,et al.   

  1. Central Hospital of Railroad,Liuzhou 545007,Guangxi Autonomy Region,China
  • Received:2010-04-13 Online:2010-10-10 Published:2016-04-18

摘要: 目的 探讨血浆置换(PE)联合血液透析滤过(HDF)治疗重型肝炎的临床效果。方法 将119例重型肝炎患者随机分为A、B、C三组,均在内科治疗的基础上,A组47例接受PE治疗,B组32例接受PE+HDF治疗,C组不接受人工肝治疗。结果 A组治愈16例,好转22例,死亡9例,B组治愈9例,好转17例,死亡6例,C组治愈7例,好转22例,死亡11例;PE或PE+HDF治疗后,患者血NO、LPS、TNF-α下降明显。结论 PE或PE联合HDF治疗重型肝炎,能显著改善临床症状、促进肝性脑病恢复,提高患者存活率。

关键词: 重型肝炎, 血浆置换, 血液透析滤过

Abstract: Objective To investigate plasma exchange(PE)and hemodiafiltration(HDF)treatment in patients with fulminant hepatitis. Methods 119 patients with severe hepatitis were randomly divided into three groups. The basic medical treatment was the same. 47 cases in group A received PE,32 in group B received with PE+HDF. Results In group A,16 patients recovered,22 improved and 9 died,in group B,9 recovered,17 improved,and 6 died,and in group C,7 recovered,22 improved and 11 died;NO,LPS,TNF alpha dropped significantly after the treatment of liver supporting. Conclusion PE and HDF treatment in patients with fulminant hepatitis can significantly decrease TBIL,NH3,NO LPS,TNF alpha,and improve the survival rate of the patients.

Key words: Severe hepatitis, Plasma exchange, Hemodiafiltration