Abstract: Objective To report the clinical features of patients with coagulation factor Ⅶ defciency and hepatitis B. Method One patients with chronic hepatitis B and coagulation factor Ⅶ defciency was reported.Result The patients had a prolonged PT and normal APTT，while he had a positive serum hepatitis B markers and normal liver function tests. Conclusion Coagulation factor Ⅶ defciency is a rare hemorrhage disease with some gene defect. A patient with prolonged PT and normal liver functions should be diagnosed carefully.

Key words: Hepatitis B, Coagulation factor Ⅶ defciency, Prothrombin time