Abstract: Objective To evaluate the efficacy of adefovir dipivoxil（ADV） on patients with chronic hepatitis B，and its association with HBV genotypes.Methods 75 patients with chronic hepatitis B were treated with ADV for 48 weeks，and the HBV genotypes were detected.Results In all patients，HBV genotype B，C and B/C were 49（65.4%），22（29.3%） and 4（5.3%），respectively;ALT normalization and HBV DNA negative rates at week 48 were 58.7% and 50.7%，HBeAg loss and HBeAg seroconversion rates were 34.9% and 1.5%，respectively;The ALT normalization and HBV DNA negative rate in genotype B group at week 12 were 26.5% and 38.8%， which came to 55.1% and 53.1% at week 48，respectively，while in genotype C group at 12 week were 13.6% and 31.8%，which came to 59.1% and 36.4% at 48 week，respectively.Conlusions The baseline HBV DNA levels affect the antiviral response to ADV，especially in patiens with HBV DNA>1×105copies/ml.There was no association between the efficacy of adefovir dipivoxil and HBV genotypes.

Key words: Hepatitis B, Adefovir dipivoxil, HBV genotypes