Abstract: Objective To study the etiologies,clinical symptoms and signs,and therapeutic options of patients with primary liver cancer （PLC）. Methods The clinical data,laboratory tests,image materials,therapeutic options and prognosis of patients who were first diagnosed with PLC between May,2011 and December,2012 were collected and analyzed retrospectively. Results Five hundred and seventy-seven patients with complete data were included, among whom the ratio of male to female was 512:65;The age ranged from 22 to 90 years,and the average age was（53.1±12.0） years;Among these patients,there were 511 patients （88.56%） who were positive for serum marker（s） of hepatitis B virus （HBV） infection,and 132 （22.9%） with a family history of HBV-related chronic liver diseases;Among 513 patients with HBV serum marker examination,91.0%（467）of patients were HBsAg positive,30.8%（158） HBeAg positive and 60.2%（309）HBeAg negative;Hepatalgia was the most common initial symptom;There were 115 patients （19.93%） who were suitable for surgery at the time of diagnosis,however,only 40.87% （47 cases） of them received hepatectomy indeed. Conclusions PLC is more common in male persons,closely associated with chronic HBV infection in China and lacks of specific clinical manifestations;The proportion of patients receive surgical procedure to total patients who are suitable for surgical therapy is still rather low,and standardized therapy according to the available guidelines should be further promoted in HCC patients in China.

Key words: Primary liver cancer, Clinical characteristics, Therapeutic options