Abstract: Objective To investigate the clinical effect of transcatheter hepatic arterial chemoembolization (TACE) combined with CT-guided precision microwave ablation on patients with primary liver cancer and its influence on immune founction. Methods 60 patients with primary liver cancer including 42 men and 18 women admitted to our hospital between January 2010 and December 2014,and they were divided into control and observation group with 30 cases in each group according to the hospitalization order. Patients in control group were treated with TACE,and in observation group received TACE combined with CT-guided precision microwave ablation. The clinical effect,2 annual survival rate,the relapse rates and the subsets of T-lymphocytes and serum alpha-L-fucosidase levels were compared between the two groups. Results At the end of three month therapy,the clinical effect in observation group was 83.3%（25/30）,significantly higher than 50%（15/30） in the control group （P<0.05）;the two annual survival rate in the observation group was 70.0%,much higher than 43.3% in the control group（P<0.05）;the relapse rate in the observation group was 10.0%, significantly lower than 36.7% in the control （P<0.05）;After therapy,the percentage of CD4⁺T-lymphocytes,CD8⁺T-lymphocytes, the ratio of CD4⁺/CD8⁺,serum alpha-L-fucosidase levels in the observation group was（39.05±4.07）%,（21.35±3.24）%,（1.67±0.21）,（17.91±2.98） u/L,markedly improved as compared to those in the control group[（28.63±3.61）%,（35.12±4.62）5,（0.96±0.11）,（26.03±4.75）u/L,respectively,P<0.05];Additionally,all patients appeared some mild reactions after TACE,such as backache,abdominal distension,nausea,etc,and they disappeared after symptomatic treatment and nursing. The adverse reactions between the two groups showed no statistically difference. Conclusion Transcatheter hepatic arterial chemoembolization combined with CT-guided precision microwave ablation have definite curative effect on patients with primary liver cancer,which could improve the survival rate,and decrease relapse rate.

Key words: Primary liver cancer, Transcatheter hepatic arterial chemoembolization, CT-guided precision, Microwave ablation, Survival