Abstract: Objective The aim of this study was to observe the long-term efficacy of radical surgery for treatment of patients with hepatic alveolus echinococcosis. Methods A total of 60 patients with hepatic alveolus echinococcosis (Child-Pugh class A in 36 cases, and class B in 24 cases) were encountered in our hospital between July 2014 and July 2019, and all underwent radical resection of the diseased foci. The patients were followed-up for 3 years. Results One week after operation, total serum bilirubin and alkalinephosphatase levels in patients with Child-Pugh class A were (17.8±6.6)μmol/L and (80.0±21.5)U/L, both significantly lower than [(21.8±7.4)μmol/L and (97.8±17.9)U/L, respectively, P＜0.05] in patients with Child-Pugh class B; the incidences of post-operational complications such as Incisional infection, pleural effusion, deep venous thrombosis, hepatic encephalopathy, refractory ascites, bile leak and renal deficiency in patients with Child-Pugh class A was 30.6%, significantly lower than 79.2%(P＜0.05) in patients with Child-Pugh class B; during three year follow-up period, three and two patients missed in patients with Child-Pugh class A and class B, respectively; the one-year and three-year survival in patients with Child-Pugh class A were 97.0%(32/33) and 93.9% (31/33), not significantly different compared to 90.9%(20/22) and 86.4%(19/22) in patients with Child-Pugh class B (Log-Rank=8.99, P=0.343); the hepatic foci relapse rate in patients with Child-Pugh class A was 12.1%(4/33), also not significantly different compared to 27.3%(6/22, x²=1.146, P=0.284) in patients with Child-Pugh class B. Conclusion Radical surgery is efficacious in treatment of patients with hepatic alveolus echinococcosis, even though with a relative high relapse post-operationally. The improvement of liver functions before operation is of very importance in order to decrease the post-operational complications.

Key words: Hepatic alveolar echinococcosis, Radical surgery, Child-Pugh grading, Complications, Relapse