Abstract: Objective The aim of this study was to investigate the evaluation of intrahepatic lesion activity by ¹⁸F-FDG PET/CT scan in patients with hepatic alveolar echinococcosis (HAE). Methods 109 patients with HAE admitted to our hospital between June 2016 and June 2018, and all patients received albendazoletreatment for six months. All patients underwent ¹⁸F-FDG PET/CT scan before and after treatment. Results PET/CT examination in 109 patients with HAEbefore treatment showed that most HAE lesions were with mixeddensity and irregular shape, with calcification,liquefaction necrosis, unclear boundary and aggressive growth. The radioactive distribution was found in the edge of the lesions, which was higher than that of the liver; PET/CT scan at six month after the treatment showed that the radiation activity around the lesions disappeared or significantly decreased in 75 cases, and the radiation distribution was slightly reduced in 34 cases; the maximum standardized uptake value of the radiation distribution in the proliferative infiltration zone in the 109 patients after the albendazole treatment was(3.6±1.4), significantly lower than 【(4.9±1.9), P＜0.05】 before treatment. Conclusion The use of ¹⁸F-FDG PET/CT scan might help evaluate the lesion activity,which could guide the albendazole treatment.

Key words: Hepatic alveolar echinococcosis, ¹⁸F-FDG, PET/CT scan, Lesion activity