Abstract: Objective The purpose of this study was to investigate the efficacy of polyene phosphatidylcholine and Fuzheng Huayu capsule, a herbal medicine, combination in the treatment of patients with non-alcoholic fatty liver diseases (NAFLD) and its effect on hepatic steatosis score (HSSu) by ultrasonography. Methods A total of 132 patients with NAFLD were recruited in our hospital between January 2018 and January 2020, and were randomly divided into control (n=66) and observation group (n=66), receiving orally polyene phosphatidylcholine or polyene phosphatidylcholine and Fuzheng Huayu combination therapy for 24 weeks. Serum tumor necrosis factor-α (TNF-α), high sensitivity C-reactive protein (hs-CRP) and interleukin-10 (IL-10) levels were assayed. The hepatic steatosis scores was evaluated by ultrasonography. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamine transferase (GGT), serum alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL - C) and low density lipoprotein cholesterol (LDL-c) levels were detected routinely. Results At the end of 24 week observation, serum ALT, AST and GGT levels in the observationgroup were (39.4±4.1)U/L, (35.8±6.6)U/L and (81.4±10.1)U/L, significantly lower than [(54.3±5.2)U/L, (50.9±7.4)U/L and (108.8±12.6)U/L, respectively, P＜0.05] in the control; blood TC, TG and LDL-C levels were (3.5±1.0)mmol/L, (2.2±0.6)mmol/L and (2.7±0.6)mmol/L, significantly lower than [(4.2±1.2)mmol/L, (2.9±0.8)mmol/L and (3.4±0.8)mmol/L, respectively, P＜0.05], while blood HDL-C level was (1.7±0.6)mmol/L, significantly higher than [(1.3±0.5)mmol/L, P＜0.05] in the control group; the hepatic steatosis score and serum TNF-α level were (0.9±0.2) and (3.5±0.8)ng/L, significantly lower than [(1.7±0.3) and (4.2±1.0)ng/L, while serum IL-10 level was (28.9±7.4)ng/L, significantly higher than (24.1±6.7)ng/L, P＜0.05] in the control. Conclusion The oral administration of polyene phosphatidylcholine and Fuzheng Huayu combination in the treatment of patients with NAFLD could improve liver function test normal and decrease blood lipids, which might be related to the intrahepatic steatosis and inflammatory reactions.

Key words: Nonalcoholic fatty liver diseases, Polyene phosphatidylcholine, Fuzheng Huayu capsule, Hepatic steatosis, Therapy