Abstract: Objective The purpose of this study was to investigate the efficacy of sofosbuvir (SOF) and ledipasvir (LDV) in patients with chronic hepatitis C (CHC). Methods 116 patients with CHC were recruited in our hospital, and all were treated with SOF and LDV without ribavirin for three months. The four indexes of liver fibrosis (FIB-4) was calculated and serum HCV RNA loads were detected by RT-PCR. The univariate and multivariate Logistic regression analyses were applied to screenthe independent impacting factors for sustained virological response (SVR) the patients got after antiviral treatment. The receiver operating characteristic (ROC) curve was applied to analyze the predictive efficacy of parameters for SVR. Results At the end of six month followed-up after the discontinuation of the regimen, serum ALT, AST levels and platelet counts in 116 patients with CHC were (32.4±6.8)U/L,(36.5±9.2)U/L and (224.6±31.9)×10⁹/L, all significantly lower than [(56.6±11.7)U/L, (64.7±11.8)U/L and (262.3±41.7)×10⁹/L, respectively, P＜0.05] at the end of treatment or [(204.3±41.6)U/L, (131.2±26.5)U/L and (313.7±53.6)×10⁹/L, respectively, P＜0.05] before treatment; the FIB-4 and serum HCV RNA load were (0.9±0.1) and (1.1±1.2)lgU/mL, both significantly lower than [(1.2±0.2) and (1.9±1.1)lgU/mL, respectively, P＜0.05] at the end of the treatment or [(1.4±0.2) and (6.4±1.3)lgU/mL, respectively, P＜0.05] before treatment; the rapid virologic response, the end of treatment virologic response and SVR in our series were 75.0%, 89.7% and 82.0%; the multivariate Logistic regression analysis showed that the FIB-4 and serum HCV RNA loads were the impacting factors for SVR (P＜0.05); the AUC was 0.875 with the sensitivity of 83.2% and the specificity of 90.5% when the combination of FIB-4＜1.65 and serum HCV RNA load equal to (6.6±0.8)lgU/mL before treatment were set as the cut-off-value. Conclusion The combination of SOF and LDV in treating patients with CHC is efficacious, and the patients at presentation with low FIB-4 and serum HCV RNA might obtain a better efficacy.

Key words: Hepatitis C, Sofosbuvir, Ledipasvir, Four indexes of liver fibrosis, Therapy