血管瘤剥脱术和肝切除术治疗肝血管瘤患者疗效研究*

doi:10.3969/j.issn.1672-5069.2022.02.032

Abstract

Abstract: Objective The aim of this study was to analyze the efficacy of hemangioma stripping and hepatectomy in the treatment of patients with hepatic hemangioma and to evaluate the infleunce of the two surgical treatment on perioperative indicators, postoperative complications and prognosis. Methods A total of 58 patients with hepatic hemangioma were recruited in our hospital between January 2019 and June 2020, out of them, 31 patients were treated with hemangioma stripping and 27 patients were treated with hepatectomy. All patients were followed-up for 6 months. The perioperative indicators, postoperative complications and postoperative recurrence of tumor were recorded in the two groups. Results The surgical time, intraoperative blood loss, postoperative abdominal drainage volume and postoperative hospital stay in hemangioma stripping-treated patients were (120.6±25.4)min, (389.3±53.8)mL, (264.5±55.7)mL and (13.9±2.4)d, all significantly shorter or less than [(148.1±28.9)min, (468.2±59.2)mL,(321.8±63.4)mL and (15.8±3.3)d, respectively, P<0.05] in patients receiving hepatectomy; the post-operational complications, such as intraperitoneal hemorrhage, bile leakage and pleural effusion in hemangioma stripping-treated patients was significantly lower than in patients receiving hepatectomy (6.5% vs. 35.0%, P<0.05); six months after operation, all hepatic hemangioma in the two groups disappeared without recurrence; five days after surgery, serum alanine aminotransferase and aspartate aminotransferase levels in hemangioma stripping-treated patients were (71.3±15.3)U/L and ((49.1±9.3)U/L, both significantly lower than [(82.9±16.8)U/L and (57.3±11.2)U/L, respectively, P<0.05] in hepatectomy-treated patients. Conclusion Hemangioma stripping and hepatectomy are both effective and safe in treating patients with hepatic hemangioma, However, hemangioma stripping has some advantages in reducing trauma and shortening postoperative recovery time. The two surgical approaches have their own indications, and the surgeons might choose the appropriate surgery for the optimal efficacy.

Key words: Hepatic hemangioma, Hemangioma stripping, Hepatectomy, Therapy

Liu Haisheng, Ning Chunmin, Sun Wenbing. Efficacy of hemangioma stripping and hepatectomy in the treatment of patients with hepatic hemangioma[J]. Journal of Practical Hepatology, 2022, 25(2): 279-282.

References

[1] Liu Z, YiL,Chen J, et al. Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma. BMC Med Imaging, 2020, 20(1):71-79.
[2] Macdonald A, Durkin N,Deganello A, et al. Historical and contemporary management of infantile hepatic hemangioma: A 30-year single-center experience. Ann Surg, 2020, 19(5):1975-1981.
[3] AbdelWahab M, El Nakeeb A, Ali M A, et al. Surgical management of giant hepatic hemangioma: Single center's experience with 144 patients. J Gastrointest Surg, 2018, 22(5):849-858.
[4] 费贤明,荚卫东.肝切除与TAE治疗肝血管瘤患者术后生存质量评价.实用肝脏病杂志,2020,23(5):140-143.
[5] 高维克,戴朝六,许永庆,等.肝血管瘤患者手术治疗后生存质量评价.中华消化外科杂志,2019,18(12):1129-1136.
[6] 国际肝胆胰协会中国分会肝血管瘤专业委员会.肝血管瘤诊断和治疗多学科专家共识(2019年版).中华消化外科杂志,2019,18(8):705-710.
[7] Zhai L L, Ju T F, Zhou C H, et al. Spontaneous rupture of giant hepatic hemangioma: misdiagnosis as gastrointestinal perforation. J Int Med Res, 2019, 47(9):4514-4521.
[8] Chan S, Tan H. A rare presentation of sudden death due to pulmonary thromboembolism possibly as a result of giant hepatic hemangioma. J Forensic Sci, 2019, 64(6):1921-1925.
[9] Zavras N, Dimopoulou A, Machairas N, et al. Infantile hepatic hemangioma: current state of the art, controversies, and perspectives. Eur J Pediatr, 2020, 179(1):66-73.
[10] Ju M, Xu F, Zhao W, et al. Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study. BMC Surg, 2020, 20(1):271-279.
[11] 高维克,戴朝六,许永庆,等.肝血管瘤患者手术治疗后生存质量评价.中华消化外科杂志,2019,18(12):1129-1135.
[12] 杨志英,谭海东,孙永亮,等.肝尾状叶巨大血管瘤的手术治疗.中华普通外科杂志,2017,32(2):153-155.
[13] Gao J, Xu L, Yang M M, et al. A severe complication of myocardial dysfunction post radiofrequency ablation treatment of huge hepatic hemangioma: a case report and literature review. Open Med, 2019, 14(1):398-402.
[14] Md Y J, Chen S, Yang K, et al. Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: a multicenter prospective study. J Am Acad Dermatol, 2021, 11(1):1-7.
[15] Lekwuttikarn R, Josephs S, Teng J M. Successful medical management of life-threatening hepatic hemangioma in neonates. Pediatrics, 2019, 144(4):e20191339.
[16] Wessman L L, Mori W S, Totoraitis K, et al. Multifocal infantile hemangiomas associated with concomitant giant hepatic rapidly involuting congenital hemangioma. Pediatr Dermatol, 2020, 37(5):972-973.
[17] Renzulli M, Ricciardi D, Clemente A, et al. Unexpected newborns in the liver : hemangiomatosis onset after hepatic resection of a giant cavernous hemangioma. Acta Gastroenterol Belg, 2019, 82(3):454-455.
[18] 周进学,王征征,李庆军,等.精准肝切除治疗邻近重要管道肝肿瘤的临床疗效.中华消化外科杂志,2017,16(2):139-143.
[19] Zhang X T,Ren W D , Song G, et al. Infantile hepatic hemangiomas associated with high-output cardiac failure and pulmonary hypertension. BMC Cardiovasc Disord, 2019, 19(1):216-221.
[20] 尹毅锐,翁佳雷,邱双健,等.腹腔镜与开腹肝切除术治疗肝血管瘤的疗效分析:倾向性评分匹配研究.复旦学报:医学版,2020,47(4):474-481.
[21] Joshi K,Bolia R, Poddar U, et al. Consumptive hypothyroidism due to diffuse hepatic hemangiomas treated with propranolol therapy. Indian Pediatr, 2020, 57(4):366-368.
[22] Wang D,Cloutier G, Fan Y , et al. Automatic respiratory gating hepatic DCEUS-based dual-phase multi-parametric functional perfusion imaging using a derivative principal component analysis. Theranostics, 2019, 9(21):6143-6156.

Efficacy of hemangioma stripping and hepatectomy in the treatment of patients with hepatic hemangioma

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