Th17/Treg细胞在原发性胆汁性肝硬化发病中的作用研究进展*

doi:10.3969/j.issn.1672-5069.2015.02.031

Abstract

Abstract: Primary biliary cirrhosis（PBC） is a kind of autoimmune diseases with unknown etiology. Th17 cells and Treg cells are two subpopulations of CD4⁺T cells,plays suppression of,or promotion of inflammatory reactions respectively. They inhibit each other in the differentiation and function. Many studies suggest that Th17 and Treg cells,and related cytokines differ in PBC patients from in healthy persons,but the exact mechanism remains unclear. In recent years,their changes in the pathogenesis of PBC has become a hot topic. This review focuses on the research about Treg cells and Th17 cells and their roles in the pathogenesis of PBC.

Key words: Primary biliary cirrhosis, Th17 cells, Treg cells

Su Lan, Yang Jinhui. T helper type 17 and T regulatory cells in primary biliary cirrhosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(2): 213-216.

References

[1] 刘海英,姚定康,屠小卿,等. 原发性胆汁性肝硬化患者中自身抗原丙酮酸脱氢酶特异性CD8 + CTL表位预测及鉴定. 中国医学科学院学报,2004,26（5）：500-504.
[2] 高会霞,刘玉珍,袁文芳. 原发性胆汁性肝硬化患者调节性T细胞及相关细胞因子与肝功能损伤的相关性研究.现代中西医结合杂志,2012,21（4）：345-347.
[3] Zhu J,Paul WE. Heterogeneity and plasticity of T helper cells. Cell Res,2010,20（1）:4-12.
[4] Park H,Li Z,Yang XO,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol,2005,6（11）:1133-1141.
[5] Bian Z,Guo Y,Ha B,et al. Regulation of the inflammatory response:enhancing neutrophil infiltration under chronic inflammatory conditions. J Immunol,2012,188（2）:844-853.
[6] 徐维家,李志,杨婷婷,等. 系统性红斑狼疮患者Th17 和Th1 细胞及其细胞因子水平的变化及临床意义. 检验医学,2013,28（5）:396-399.
[7] Weaver CT,Harrington LE,Mangan PR,et al. Th17:an effector CD4 T cell lineage with regulatory T cell ties. Immunity,2006,24（6）:677-688.
[8] Mckarns SC,Schwartz RH. Distinct effects of TGF-beta 1 on CD4 + and CD8 + T cell survival,division,and IL-2 production:a role for T cell intrinsic Smad3. J Immunol,2005,174（4）:2071-2083.
[9] Ivanov II,McKenzie BS,Zhou L,et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+T helper cells. Cell,2006,126（6）:1121-1133.
[10] Mangan PR,Harrington LE,O'Quinn DB,et al. Transforming growth factor-beta induces development of the T（H）17 lineage. Nature,2006,441（7090）:231-234.
[11] Bettelli E,Carrier Y,Gao W,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature,2006,441（7090）:235-238.
[12] Zhou L,Ivanov II,Spolski R,et al. IL-6 programs T（H）-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol,2007,8（9）:967-974.
[13] McGeachy MJ,Chen Y,Tato CM,et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol,2009,10（3）:314-324.
[14] Muratori L,Longhi MS. The interplay between regulatory and effector T cells in autoimmune hepatitis:Implications for innovative treatment strategies. J Autoimmun,2013,46:74-80.
[15] Lafdil F,Miller AM,Ki SH,et al. Th17 cells and their associated cytokines in liver diseases. Cell Mol Immunol,2010,7（4）:250-254.
[16] Zhao L,Qiu de K,Ma X. Th17 cells:the emerging reciprocal partner of regulatory T cells in the liver. J Dig Dis,2010,11（3）:126-33.
[17] Hammerich L,Heymann F,Tacke F. Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol,2011,2011:345803.
[18] Ye C,Li WY,Zheng MH,et al. T-helper 17 cell:a distinctive cell in liver diseases. Hepatol Res, 2011, 41（1）:22-29.
[19] Lan RY,Salunga TL,Tsuneyama K,et a1. Hepatic IL-17responses in human and murine primary biliary cirhosis. J Autoimmun,2009,32（1）:43-51.
[20] Rong G,Zhou Y,Xiong Y,et a1. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis:the serum cytokine profile and peripheral cell population.Clin Exp Immunol,2009,156（2）:217-225.
[21] Harada K, Shimoda S,Sato Y,et al. Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol,2009,157（2）:261-270.
[22] 邓日辉, 周迎春, 陈曲波. 白细胞介素-1β和白细胞介素-23对原发性胆汁性肝硬化患者Th17细胞的影响.广东医学,2014,35（8）:1238-1240.
[23] Wakabayashi K,Lian ZX,Moritoki Y,et al. IL-2 receptor α -/- mice and the development of primary biliary cirrhosis. Hepatology,2006,44（5）:1240-1249.
[24] 彭辉,陈维贤,陈敏. IL-17与B淋巴细胞刺激因子在原发性胆汁性肝硬化患者中的表达及临床意义. 临床检验杂志,2011,29（4）:254-256.
[25] Sakaguchi S,Sakaguchi N,Asano M,et a1. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains（CD25）. Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J lmmunol,1995,155（3）:1151-1164.
[26] Sakaguchi S,Toda M,Asano M,et a1. T cell-mediated maintenance of natural self-tolerance:its breakdown as a possible cause of various autoimmune diseases. J Autoimmun,1996,9（2）:211-220.
[27] Sakaguchi S,Miyara M,Costantino CM,et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol, 2010,10（7）:490-500.
[28] Sakaguchi S. Naturally arising CD4 + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol,2004,22:531-562.
[29] Bernuzzi F,Fenoglio D,Battaglia F,et al. Phenotypical and functional alterations of CD8 + regulatory T cells in primary biliary cirrhosis. J Autoimmun,2010,35（3）:176-180.
[30] Liu B,Shi XH,Zhang FC,et al. Antimitochondrial antibody-negative primary biliary cirrhosis:a subset of primary biliary cirrhosis. Liver Int,2008,28（2）:233-239.
[31] 许茵,杨小娟,蒯守刚. 原发性胆汁性肝硬化患者外周血CD4+CD25 + Foxp3 + 调节性T细胞检测及其临床意义. 中国实验诊断学,2014,18（4）:592-594.
[32] Sasaki M,Ikeda H,Sawada S,et al. Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis. J Clin Pathol,2007,60（10）:1102-1107.
[33] Bernuzzi F,Fenoglio D,Battaglia F,et al. Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis. J Autoimmun,2010,35（3）:176-180.
[34] 王兰,杨瑞宁,张丽. Th17细胞和调节性T细胞与自身免疫性肝病的关系. 国际检验医学杂志,2014,35（8）:1022-1025.
[35] Reizis B,Colonna M,Trinchieri G,et al. Plasmacytoiddendritic cells:one-trick ponies or workhorses of the immune system Nat Rev Immunol,2011,11（8）:558-565.
[36] Gautreau L,Chabannes D,Heslan M,et al. Modulationof regulatory T cell-Th17 balance by plasmacytoid dendritic cells. J Leukoc Biol,2011,90（3）:521-527.
[37] Voo KS,Wang YH,Santori FR,et al. Identification of IL-17-producing FOXP3 + regulatory T cells in humans. Proc Natl Acad Sci U S A,2009,106（12）:4793-4798.
[38] Lina C,Conghua W,Nan L,et al. Combined treatment of etanercept and MTX reverses Th1/Th2,Th17/Treg imbalance in patients with rheumatoid arthritis. J Clin Immunol,2011,31（4）:596-605.
[39] Fenoglio D,Bernuzzi F,Battaglia F,et al. Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases. Autoimmun Rev,2012,12（2）:300-304.
[40] Bernuzzi F,Fenoglio D,Battaglia F,et al. Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis. J Autoimmun,2010,35（3）:176-180.

T helper type 17 and T regulatory cells in primary biliary cirrhosis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Yang Caiyong, Chen Na, Li Kui, et al.. Clinical significance of peripheral blood Treg and Th17 cells in patients with chronic hepatitis C and hepatitis C-induced liver cirrhosis [J]. Journal of Practical Hepatology, 2019, 22(6): 868-871.
[2]	Chen Meimei, Duan Xiaoyan, Cao Haixia, et al.. Improvement of clinical symptoms and serum hepatic fibrosis markers in patients with primary biliary cirrhosis by compound Biejiaruangan tablets [J]. Journal of Practical Hepatology, 2019, 22(6): 880-883.
[3]	Liu Yingchuan, Zhao Pengcheng, You Ting, et al.. Changes of peripheral blood 25-（OH） 2-D3 levels and peripheral T lymphocyte subsets in patients with primary biliary cirrhosis receiving vitamin D supplementation and ursodeoxycholic acid treatment [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(6): 907-910.
[4]	Liu Jinguo, Wang Baokui. Efficacy of Fufangbiejia Ruanganpian and ursodeoxycholic acid combination in the treatment of patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(3): 340-343.
[5]	Qin Wei, Chen Yuping, Yang Zhao, et al. Expression of transforming growth factor β-1 in liver tissues of patients with primary biliary cirrhosis and its relationship with liver fibrosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(2): 237-240.
[6]	Chen Xiaojun, Song Yang. Changes of peripheral blood T lymphocyte subsets and efficacy of ursodesoxycholic acid and vitamin D combination in treatment of patients with primary biliary cholangitis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(1): 80-83.
[7]	Tao Mingling, Zhang Shibin, Wu Yanjing, et al.. Non-invasive predictors of esophageal varices in patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(4): 439-442.
[8]	Liu Funa, Liu Jiangkui, Shen Yihui.. Efficacy of ursodeoxycholic acid and prednisolone combination in treatment of patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(4): 443-446.
[9]	Guo Rui, Tan Jin.. A randomized controlled trial of ursodeoxycholic acid in treating patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(1): 109-110.
[10]	Han Yongbin， Liu Xin，Wang Aifang， et al.. Primary biliary cirrhosis misdiagnosed as bone marrow hyperplasia syndrome: A case report [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(6): 747-748.
[11]	Hao Jianhong,Hao Haiyan,Hu Yiling. Clinical features of primary biliary cirrhosis: An analysis of 94 cases [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(3): 352-353.
[12]	Zhou Xinren, Wang Fang, Yun Shenghao. Intrahepatic transplantation of umbilical cord blood stem cells in treatment of patients with decompensated primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(2): 219-220.
[13]	Wang Gui， Wang Jiangbin.. Features of elderly patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(6): 573-574.
[14]	Liu Jingjing， Li Qingyan， Liu Chunhua.. HLA-DR mRNA levels,Th17 and CD4⁺CD25⁺Treg cell percentages in peripheral blood mononuclear cells in patients with liver failure [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(6): 598-602.
[15]	Kong Xianglu，Guo Xiaoxia. Systemic review of Chinese herbal medicine combined with ursodeoxycholic acid in treatment of patients with primary biliary cirrhosis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(4): 379-382.