腹腔镜胆囊切除术治疗胆囊结石伴慢性胆囊炎患者治疗效果分析

doi:10.3969/j.issn.1672-5069.2021.02.032

Abstract

Abstract: Objective To investigate the efficacy of laparoscopic cholecystectomy (LC) in the treatment of patients with gallstones and chronic cholecystitis.Methods 70 patients with gallstones and chronic cholecystitis were enrolled in our hospital between March 2018 and March 2020, and were randomly divided into control group (n=35) and observation group (n=35). The patients in the control group were treated with open cholecystectomy with small incision, and those in the observation group were treated with LC. Serum gastrin (GAS), vactive intestinal peptide (VIP) and motilin (MOT) levels were detected by ELISA.Results The operationtime in the observation group was (60.6 ±6.5) min, which was significantly shorter than that in the control group [(95.4±7.2) min, P<0.05], the postoperative hospital stay was (5.3±1.4) d, which was significantly shorter than that in the control group [(7.7±2.5) d, P<0.05], and the intraoperative blood loss was (42.3±12.4) mL, which was significantly less than that in the control group [(124.5±21.7) mL, P <0.05]; serum glutamyl transferase (GGT) level in the observation group was (41.4±9.3) U/L, which was significantly lower than in the control group [(65.1±10.5) U/L, P<0.05], serum aspartate aminotransferase (AST) level was (45.3±17.5) U/L, which was significantly lower than in the control group [(71.2±19.7)U/L, P<0.05], and serum alanine aminotransferase (ALT) level was (28.0±20.5) U/L, which was significantly lower than in the control group [ (59.5±22.8) U/L, P<0.05]; serum C-reactive protein (CRP) level was (28.4±8.3) ng/L, which was significantly lower than in the control group [(35.7±8.7) ng/L, P<0.05], serum interleukin-6 (IL-6) level was (42.4±5.3) ng/L, which was significantly lower than that in the control group [(47.7±6.7) ng/L, P<0.05], serum tumor necrosis factor-ɑ (TNF-ɑ) level was (1.9±0.5) μg/L, which was significantly lower than that in the control group [(4.7±0.9) μg/L, P<0.05]; serum GAS level was (129.5±12.4) ng/L, which was significantly higher than that in the control group [(112.7±10.6) ng/L, P<0.05], serum MOT level was (242.4±38.7) ng/L, which was significantly higher than that in the control group [(197.6±42.4) ng/L, P<0.05], and serum VIP level was (18.2±3.7) pg/mL, which was significantly lower than that in the control group [(22.8±5.3) pg/mL, P<0.05]; after operation, the incidence of complications in the observation group was 8.6%, significantly lower than that in the control group (20.0%, P<0.05).Conclusion The application of laparoscopic cholecystectomy for treatment of patients with gallstones and chronic cholecystitis is efficacious, which might significantly decrease serum VIP level and increase serum GAS and MOT levels, improve gastrointestinal function restoration, and relieve inflammation reaction.

Key words: Gallstones, Chronic cholecystitis, Laparoscopic cholecystectomy, Efficacy, Gastrin, motilin, Vasoactive intestinal peptide

Luo Deng, Lai Xihua, Liu Shouji. Efficacyof laparoscopic cholecystectomy in the treatment of patients with gallstones and chronic cholecystitis[J]. Journal of Practical Hepatology, 2021, 24(2): 276-279.

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Efficacyof laparoscopic cholecystectomy in the treatment of patients with gallstones and chronic cholecystitis

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