Abstract: Objective The aim of this study was to compare the clinical features of patients with autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and AIH/PBC overlap syndrome (AIH/PBC OS). Methods 92 patients with autoimmune liver diseases were admitted to the Third People's Hospital, Nantong city between December 2017 and February 2019, including AIH in 35, PBC in 30 and AIH/PBC OS in 27. The clinical data were compared. Results The ages, gender, body mass index and disease periods in patients with AIH, PBC and AIH/PBC were not significantly different(P>0.05); the incidences of clinical symptoms such as fatigue, abdominal distension, anorexia, fever and pruritus in the three groups were not much different(P>0.05); the jaundice was more common and higher serum ALP and GGT in patients with PBC and in with AIH/PBC OS, while the patients with AIH had higher serum ALT and AST levels (P<0.05); the TT was significantly longer in patients with AIH than in patients with PBC or AIH/PBC OS (P<0.05); the blodd Hb level in patients with AIH was significantly lower than in other two groups (P<0.05); the prevalence of serum ASMA in patients with AIH was 14.3%, significantly higher than 0.0% and 0.0% in other two groups(P<0.05), the positivity rates of AMA/AMA-M2 in patients with PBC and with AIH/PBC OS were 93.3% and 92.6%, while that in patients with AIH was 0.0%(P<0.05); serum immunoglobulin levels and the coincidence of hyperthyroidism, SLE, Sjogren's syndrome, rheumatoid arthritis, type two diabetes mellitus and chronic glomerulonephritis in the three groups were not significantly different(P>0.05). Conclusion The patients with AIH, PBC and AIH/PBC OS have sometimes similar clinical symptoms and signs, but there are obvious differences in biochemical and autoimmune antibodies, which might help the clinicians to deal with autoimmune liver diseases appropriately.

Key words: Autoimmune liver diseases, Autoimmune hepatitis, Primary biliary cholangitis, AIH/PBC overlap syndrome, Clinical features