自身免疫性肝炎患者血清趋化因子和GP73水平变化及其临床意义研究

doi:10.3969/j.issn.1672-5069.2020.06.017

Abstract

Abstract: Objective The aim of this study was to investigate the changes of serum chemokines and golgi glycoprotein 73 (GP73) levels in patients with autoimmune hepatitis (AIH) and their clinical significance. Methods 46 patients with AIH and 46 healthy persons were recruited in our hospital between March 2018 and March 2019, and liver biopsies were performed in patients with AIH. The histopathological activities were divided into mild, moderate and severe degrees. Serum chemokine C-C-receptor 6 and 20 (CCR6 and CCL20), chemmokine C-C-ligand 10 (CXCL10) and GP73 levels were detected by ELISA. Results Serum CCR6, CCL20, CXCL10 and GP73 levels in patients with AIH were (112.4±59.3)pg/mL, (186.5±71.8)pg/mL, (81.5±42.0)pg/mL and (171.4±62.5)ng/mL, significantly higher than 【(75.8±32.6)pg/mL,(123.7±42.2)pg/mL, (53.9±28.1)pg/mL and (83.1±35.2)ng/mL, respectively, P<0.05】 in healthy persons; serum CCR6, CCL20, CXCL10 and GP73 levels in 10 patients with severe AIH were (174.2±81.4)pg/mL, (271.5±99.7)pg/mL, (162.7±83.1) pg/mL and (278.3±91.5)ng/mL, all much higher than 【(124.5±55.3)pg/mL,(198.6±66.9)pg/mL,(88.4±46.8)pg/mL and (186.2±75.8)ng/mL, respectively, P<0.05】 in 14 patients with moderate AIH or 【(83.5±34.5)pg/mL, (155.6±51.0)pg/mL,(42.6±22.7)pg/mL and (123.9±58.9)ng/mL, respectively, P<0.05 in 22 patients with mild AIH; serum CCR6, CCL20, CXCL10 and GP73 levels in 26 patients with hepatic G3-4 were (154.5±28.1)pg/mL, (201.6±56.3)pg/mL, (98.4±56.1)pg/mL and (196.2±59.78)ng/mL, all significantly higher than 【(73.5±34.8)pg/mL, (135.6±41.7)pg/mL, (62.5±20.1)pg/mL and (93.9±33.9)ng/mL, respectively, P<0.05】 in 20 patients with hepatic G1-2. Conclusion Serum CCR6, CCL20, CXCL10, and GP73 levels elevates greatly in patients with autoimmune hepatitis, and as the disease deteriorate, they increase obviously. The detection the serum parameters might monitor the illness progress, which needs multi-central investigation.

Key words: Autoimmune hepatitis, Chemokine C-C-motif receptor 6, Chemokine C-C-motif ligand 20, Chemokine ligand 10, Glycosyl glycoprotein 73

Ling Jing, Zhang Youjian, Song Xiongfeng. Changes of serum chemokines and GP73levels in patients with autoimmune hepatitis[J]. Journal of Practical Hepatology, 2020, 23(6): 825-828.

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Changes of serum chemokines and GP73levels in patients with autoimmune hepatitis

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