Abstract: Objective The aim of this study was to analyze the influencing factors of post-operational complications in patients with intrahepatic stone (IHS) after percutaneous transhepatic cholangioscopic lithotomy (PTCSL).Methods 115 patients with IHS were admitted to the Department of Digestive Diseases in our hospital between May 2015 and May 2019, and 60 received PTCSL and 55 received open operation. The factors impacting the post-operational complications were retrospectively evaluated by Logistic analysis. Results The total successful operation were carried out in our series, and the stones were pull out in the two groups; the incidence of postoperative complications in the PTCSL group was 21.7%, significantly lower than that in the laparotomy group (49.1%, P<0.05), of which, one case of lower limb deep vein thrombosis occurred in the PTCSL group, and four cases in open laparotomy group, all beening found early by color Doppler ultrasonography and improved after active anticoagulant therapy; low serum albumin level before operation, bleeding during operation, biliary tract operation history and bile multi-drug resistant bacteria infection after operation were the factors affecting complications in PTCSL group (P<0.05), and the Logistic analysis showed that low pre-operative serum albumin level [OR(95%CI) :0.5 (0.3-0.9)], hemorrhage during operation [OR(95%CI): 2 (1.4-3)], biliary tract surgery history [OR(95%CI):9 (1.3-2.7)], and bile multidrug-resistant bacteria infection [OR(95%CI):2.2 (1.2- 4.5)]were the independent risk factors for complications in the PTCSL group (P<0.05). Conclusion Compared with conventional laparotomy, PTCSL could greatly reduce the incidence of post-operational complications, which worth further investigation.

Key words: Intrahepatic stone, Percutaneous transhepatic cholangiostomy and electronic choledochoscope lithotomy: Complications, Influencing factors, Logistic analysis