JOURNAL OF PRACTICAL HEPATOLOGY ›› 2015, Vol. 18 ›› Issue (3): 321-324.doi: 10.3969/j.issn.1672-5069.2015.02.031

• Orignal Article • Previous Articles     Next Articles

Heme oxygenase-1 in the pathogenesis of chronic liver diseases

Ji Xiaoqin, Li Lei   

  1. Department of Infectious Diseases, Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China[Abstract] Heme oxygenase-1(HO-1) is a microsomal enzyme and rate-limiting enzyme that catalyzes the degradation of heme into biliverdin, iron atoms and carbon monoxide (CO). It is reported that HO-1 and its breakdown products play vital physiological roles in anti-inflammation, anti-oxidation and regulation of apoptosis. Its roles in the pathogenesis of liver diseases in recent years have gradually be elucidated,and it is promising for an option in the treatment of chronic liver disease in the future. In this paper,we will review the research progress about HO-1 in the viral hepatitis,liver fibrosis,hepatocellular carcinoma and hepatic ischemia-reperfusion injury.
  • Received:2014-12-02 Online:2015-05-10 Published:2016-02-19

Key words: Viral hepatitis, Hepatocellular carcinoma, Ischemia-reperfusion injury, Heme oxygenase-1