Journal of Practical Hepatology ›› 2019, Vol. 22 ›› Issue (6): 934-937.doi: 10.3969/j.issn.1672-5069.2019.06.040

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Diagnostic value of serum protein induced by vitamin K absence or antagonist II for hepatocellular carcinoma

Xing Hao, Han Jun, Yang Tian.   

  1. Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Naval Medical University,Shanghai 200438,China
  • Received:2018-08-20 Online:2019-11-13 Published:2019-11-13

Abstract: Primary liver cancer (PLC) is one of the most common malignant tumors in China. Early diagnosis of liver cancer is crucial for the outcome of patients with PLC. Protein induced by vitamin K absence or antagonist II(PIVKA-II) is a new serum tumor marker documented in recent years. It has a diagnostic value for hepatocellular carcinoma,reportedly better than the widely used serum tumor marker alpha-fetoprotein (AFP). In this paper,we reviewed the progress of PIVKA-II in the fundamental research and clinical application.

Key words: Hepatocellular carcinoma, Tumor marker, Protein induced by vitamin K absence or antagonist II, Diagnosis