Abstract: Objective The purpose of this study was to investigate the correlation of polymorphism of acetaldehyde dehydrogenase 2 （ALDH2） rs671 to morbidity in individuals prone to nonalcoholic fatty liver disease （NAFLD）. Methods Transient elastography and sequencing of ALDH2 rs671 were performed in 120 subjects. The odd ratio and confidence interval were calculated by Logistic analysis. Results Out of the 120 individuals,73 had NAFLD and 47 had not by the controlled attenuation parameter;the proportions of ALDH2 genotype GA/AA were 52.1% in the fatty liver group,and 34.0% in the non-fatty liver group（P<0.05）;out of female and overweight,the proportions of GA/AA type（48.8% vs. 53.3%）in the fatty liver group were both significantly higher than in non-fatty liver group （22.2% vs.23.1%,P<0.05）;Logistic analysis revealed that carriers of GA/AA type was at 3.756 -fold higher risk of NAFLD compared with non-carriers;the carriers of GA/AA type had significantly higher body weight,hip circumference and waist height ratio（P<0.05）,and serum GGT level in carriers of GA/AA type was（55.57±99.97） U/L,significantly higher than that in carriers of GG type【（38.17±48.02） U/L,P<0.05】. Conclusion The mutation of ALDH2 rs671 might increase the risk of having NAFLD,which needs further investigation.

Key words: Nonalcoholic fatty liver disease, Acetaldehyde dehydrogenase 2, Single nucleotide polymorphism, Disease hazard